Coumermycin A1 CAS: 4434-05-3
MF: C55H59N5O20
MW: 1110.08
An activator of JAK2 and Raf-1.

Coumermycin A1 (CAS 4434-05-3)

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同義語 Notomycin
アプリケーション: An activator of JAK2 and Raf-1
CAS 番号: 4434-05-3
Molecular Weight: 1110.08
Molecular Formula: C55H59N5O20
* Refer to Certificate of Analysis for lot specific data (including water content).
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Coumermycin A1, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A1 can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.


参考文献

1. Farrar, M.A. and Alberol-Ila, R.M. 1996. Nature. 383: 178-181. PMID: 8774884
2. Tsai, F.T., et al. 1997. Proteins. 28: 41-52. PMID: 9144789
3. Mizuguchi, R. and Hatakeyama, M. 1998. J. Biol. Chem. 273: 32297-32303. PMID: 9822709
4. Mohi, M.G., et al. 1998. Mol. Biol. Cell. 9: 3299-3308. PMID: 9843570

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml).
保存方法 :
Store at room temperature
Refractive Index :
n20D 1.68
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
UX9375000
PubChem CID :
54678496
MDL Number :
MFCD00057312
Beilstein Registry :
470805
SMILES :
CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CNC(=C5C)C(=O)NC6=C(C7=C(C(=C(C=C7)OC8C(C(C(C(O8)(C)C)OC)OC(=O)C9=CC=C(N9)C)O)C)OC6=O)O)O)C)O

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Coumermycin A1  参考文献

See how others have used Coumermycin A1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29885817  Bassa, BV. et al. 1999. Neuropharmacology. 277: F328-37.

PMID: # 30054044  Biochem. Biophys. Res. Commun. 503: 1747-1753.

Citations 1 to 2 of 2 total
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