Date published: 2026-7-26

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Citric Acid-2,2,4,4-d4 (CAS 147664-83-3)

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Alternate Names:
2-Hydroxy-1,2,3-propanetricarboxylic-d4 Acid; Chemfill-d4; Citretten-d4
Application:
Citric Acid-2,2,4,4-d4 is a labeled version of Citric Acid
CAS Number:
147664-83-3
Molecular Weight:
196.15
Molecular Formula:
C6H4D4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Citric Acid-2,2,4,4-d4 is a stable isotope of citric acid, a key intermediate in the citric acid cycle, known as the Krebs cycle. This deuterated form of citric acid is used as a tracer in metabolic studies, as the deuterium atoms can be tracked through various metabolic pathways. Citric Acid-2,2,4,4-d4 can provide detailed information on the utilization of citric acid in the production of ATP, the energy currency of the cell.


Citric Acid-2,2,4,4-d4 (CAS 147664-83-3) References

  1. Combining metabolomic non-targeted GC×GC-ToF-MS analysis and chemometric ASCA-based study of variances to assess dietary influence on type 2 diabetes development in a mouse model.  |  Ly-Verdú, S., et al. 2015. Anal Bioanal Chem. 407: 343-54. PMID: 25432303
  2. The memory of iron stress in strawberry plants.  |  Gama, F., et al. 2016. Plant Physiol Biochem. 104: 36-44. PMID: 27010743
  3. Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy.  |  Delplancke, TDJ., et al. 2018. Sci Rep. 8: 36. PMID: 29311683
  4. Improving liquid chromatography-tandem mass spectrometry determination of polycarboxylic acids in human urine by chemical derivatization. Comparison of o-benzyl hydroxylamine and 2-picolyl amine.  |  Gomez-Gomez, A., et al. 2019. J Pharm Biomed Anal. 164: 382-394. PMID: 30466023
  5. Changes in the concentration of organic acids in roots and leaves of carob-tree under Fe deficiency.  |  Correia, PJ., et al. 2014. Funct Plant Biol. 41: 496-504. PMID: 32481008
  6. Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension.  |  Yi, J., et al. 2022. J Pharm Biomed Anal. 212: 114662. PMID: 35202944
  7. Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments.  |  Rauckhorst, AJ., et al. 2022. Mol Metab. 66: 101596. PMID: 36100179
  8. Pharmacokinetics and Tissue Distribution of 13C-Labeled Succinic Acid in Mice.  |  Jung, Y., et al. 2022. Nutrients. 14: PMID: 36432443
  9. Comparison of Portable and Benchtop Near-Infrared Spectrometers for the Detection of Citric Acid-adulterated Lime Juice: A Chemometrics Approach.  |  Jahani, R., et al. 2022. Iran J Pharm Res. 21: e128372. PMID: 36942059

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Citric Acid-2,2,4,4-d4, 10 mg

sc-207445
10 mg
$443.00