Chk2 Antibody (19): sc-136251
- Chk2 Antibody (19) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 31-234 of Chk2 of mouse origin
- recommended for detection of Chk2 of mouse, rat and human origin by WB, IP and IF
- See Chk2 (A-11): sc-17747 for Chk2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Chk2 Antibody (19). This work is in progress.
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Chk2 Antibody (19) is a mouse monoclonal IgG1 light chain antibody that detects Chk2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Chk2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. Upon DNA damage, Chk2 is activated and phosphorylates various substrates, including Cdc25C, which leads to the inhibition of its phosphatase activity. This inhibition prevents premature entry into mitosis, allowing cells time to repair DNA damage before division. Chk2′s ability to phosphorylate other proteins, such as the cell cycle regulator Wee1, further underscores Chk2′s importance in maintaining genomic stability. Anti-Chk2 antibody (19) serves as an essential tool for researchers studying cell cycle regulation and DNA damage response mechanisms, providing insights into pathways that protect against tumorigenesis and diseases associated with genomic instability.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk2 Antibody (19) | sc-136251 | 50 µg/0.5 ml | $322.00 |