CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4): sc-59112
- CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) is a rat monoclonal IgG2a, cited in 7 publications, provided at 200 µg/ml
- raised against concanavalin A-stimulated spleen cells of mouse origin
- Anti-CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) is recommended for detection of CD71 of mouse and rat origin by WB, IP, IF and FCM
- Anti-CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4). This work is in progress.
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SEE ALSO...
CD71 Antibody (YTA 74.4) is a rat monoclonal IgG2a antibody that recognizes CD71 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD71 (YTA 74.4) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD71, also known as transferrin receptor (TFR), is a type II membrane glycoprotein essential for iron homeostasis through receptor-mediated endocytosis. This process supports DNA synthesis and cellular proliferation, as iron serves as a crucial cofactor for many enzymes. CD71 shows high expression in proliferating cells, reticulocytes, and erythroid precursors, with increased levels in activated lymphocytes, monocytes, and macrophages during immune responses. CD71 expression extends to most dividing cells and brain endothelium, indicating broad physiological significance. A second transferrin receptor, TFR2, also facilitates transferrin-bound iron uptake, primarily in the liver, contributing to iron regulation. TFR2 gene mutations can cause hereditary hemochromatosis type III (HFE3), an iron overload disorder common among Caucasians, highlighting CD71′s importance in iron metabolism and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) | sc-59112 | 200 µg/ml | $322.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) AC | sc-59112 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) HRP | sc-59112 HRP | 200 µg/ml | $322.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) FITC | sc-59112 FITC | 200 µg/ml | $336.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) PE | sc-59112 PE | 200 µg/ml | $349.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 488 | sc-59112 AF488 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 546 | sc-59112 AF546 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 594 | sc-59112 AF594 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 647 | sc-59112 AF647 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 680 | sc-59112 AF680 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (YTA 74.4) Alexa Fluor® 790 | sc-59112 AF790 | 200 µg/ml | $364.00 |