CD206/Mannose Receptor/MMR Antibody (6A598): sc-70585

CD206 Antibody (6A598) is a mouse monoclonal IgG1 kappa light chain antibody raised against CD206 of human origin, detecting CD206 from mouse, rat, and human origins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD206, also known as the Mannose Receptor (MR), Macrophage Mannose Receptor (MMR), or Mannose Receptor C Type 1 (MRC1), is a type I transmembrane receptor protein predominantly expressed on the surface of macrophages, immature dendritic cells, hepatic and lymphatic endothelial cells, retinal pigment epithelium (RPE), and mesangial cells. This cell surface localization enables CD206 to function as a phagocytic and endocytic receptor, recognizing carbohydrate ligands on the surfaces of pathogens and facilitating their uptake and clearance by the immune system. The extracellular portion of CD206 includes eight C-type carbohydrate recognition domains (CRDs) clustered together to achieve high-affinity binding to saccharides like mannose, fucose, and N-acetylglucosamine present on bacteria, fungi, and viruses. CD206 is unique among C-type lectins for containing multiple CRDs, enhancing its ability to bind a wide range of pathogenic organisms. By mediating the endocytosis of glycoproteins and enabling phagocytic engulfment of pathogens, CD206 plays a critical role in innate immunity and the rapid clearance of mannose-bearing serum glycoproteins during inflammation, although CD206 does not initiate the inflammatory response itself. Anti-CD206 antibody (6A598) provides a valuable tool for researchers to study the expression and function of CD206 across multiple species, contributing to advancements in immunological research and potential therapeutic developments.

The preferred CD206/Mannose Receptor/MMR antibody is CD206/Mannose Receptor/MMR Antibody (D-1): sc-376108.