CCK-BR Antibody (4A5): sc-53522
- CCK-BR Antibody (4A5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant CCK-BR of rat origin
- recommended for detection of CCK-BR of mouse, rat and human origin by IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCK-BR Antibody (4A5) for IHC(P) applications. These reagents are now offered in bundles with CCK-BR Antibody (4A5) (see ordering information below).
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CCK-BR Antibody (4A5) is a mouse monoclonal IgG1 antibody that detects CCK-BR in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). CCK-BR, or cholecystokinin B receptor, plays a crucial role in mediating the physiological effects of its ligands, gastrin and cholecystokinin, which are vital for digestive processes and appetite regulation. Anti-CCK-BR antibody (4A5) recognizes a receptor predominantly located in the gastrointestinal tract and the central nervous system, where CCK-BR influences various functions such as gastric acid secretion, smooth muscle contraction, and neurotransmission related to satiety and anxiety. The presence of CCK-BR in these locations underscores its importance in both digestive health and neuroregulation, making CCK-BR a significant target for therapeutic interventions in gastrointestinal and central nervous system disorders. CCK-BR monoclonal antibody (4A5) serves as an essential tool for researchers aiming to explore the intricate signaling pathways involving CCK-BR and its potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCK-BR Antibody (4A5) References:
- Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies. | Behr, TM. and Béhé, MP. 2002. Semin Nucl Med. 32: 97-109. PMID: 11965605
- Radiolabeling approaches for cholecystokinin B receptor imaging. | Aloj, L., et al. 2002. Biopolymers. 66: 370-80. PMID: 12658724
- Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells. | Mjønes, P., et al. 2018. Horm Cancer. 9: 40-54. PMID: 28980157
- Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction. | Westlund, KN., et al. 2021. Neurobiol Pain. 10: 100067. PMID: 34458647
- Cholecystokinin B receptor gene polymorphism (rs2941026) is associated with anxious personality and suicidal thoughts in a longitudinal study. | Lvovs, A., et al. 2022. Acta Neuropsychiatr. 34: 201-211. PMID: 34924075
- Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas. | Smith, JP., et al. 2021. Biomolecules. 11: PMID: 34944412
- Cholecystokinin B receptor antagonists for the treatment of depression via blocking long-term potentiation in the basolateral amygdala. | Zhang, X., et al. 2023. Mol Psychiatry. 28: 3459-3474. PMID: 37365241
- Rapid Generation and Molecular Docking Analysis of Single-Chain Fragment Variable (scFv) Antibody Selected by Ribosome Display Targeting Cholecystokinin B Receptor (CCK-BR) for Reduction of Chronic Neuropathic Pain. | Kunamneni, A., et al. 2023. Int J Mol Sci. 24: PMID: 37446213
- Implicating the cholecystokinin B receptor in liver stem cell oncogenesis. | Gay, MD., et al. 2024. Am J Physiol Gastrointest Liver Physiol. 326: G291-G309. PMID: 38252699
- Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice. | Zhang, N., et al. 2024. Alzheimers Res Ther. 16: 109. PMID: 38750512
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCK-BR Antibody (4A5) | sc-53522 | 200 µg/ml | $322.00 | |||
CCK-BR Antibody (4A5): m-IgG Fc BP-HRP Bundle | sc-536980 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCK-BR Antibody (4A5): m-IgGκ BP-HRP Bundle | sc-534159 | 200 µg Ab; 40 µg BP | $361.00 | |||
CCK-BR Antibody (4A5): m-IgG1 BP-HRP Bundle | sc-544938 | 200 µg Ab; 20 µg BP | $361.00 |