CALR3抗体(1H2): sc-134295

CALR3 Antibody (1H2) is an IgG_2b κ mouse monoclonal CALR3 antibody (also designated CALR3 antibody) suitable for the detection of the CALR3 protein of human origin by WB, IP and ELISA. CALR3 Antibody (1H2) is available as the non-conjugated anti-CALR3 antibody. Members of the calreticulin (CRT) family are calcium-binding chaperones that are localized to the endoplasmic reticulum or sarcoplasmic reticulum in eukaryotes. Plant CRTs seem to have different properties than their animal counterparts and may be significant during growth and development, as well as biotic and abiotic stress responses. Calreticulin-3, also called CRT2 (calreticulin-2), is a 384 amino acid endoplasmic reticular (ER) protein that contains two calcium binding domains, a P-domain and a C-domain. Calreticulin-3 assists in the calreticulin/calnexin cycle, where it is involved in protein-folding, oligomeric assembly and quality control in the ER. With specific expression in testis, CALR3 has been implicated as a cancer-testis antigen due to its frequent expression in various cancers.

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References:

1. Calreticulin, a multifunctional Ca2+ binding chaperone of the endoplasmic reticulum.  |  Michalak, M., et al. 1998. Biochem Cell Biol. 76: 779-85. PMID: 10353711
2. Calreticulin: one protein, one gene, many functions.  |  Michalak, M., et al. 1999. Biochem J. 344 Pt 2: 281-92. PMID: 10567207
3. The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.  |  Corbett, EF., et al. 2000. J Biol Chem. 275: 27177-85. PMID: 10842171
4. Identification of a novel calreticulin isoform (Crt2) in human and mouse.  |  Persson, S., et al. 2002. Gene. 297: 151-8. PMID: 12384296
5. Phylogenetic analyses and expression studies reveal two distinct groups of calreticulin isoforms in higher plants.  |  Persson, S., et al. 2003. Plant Physiol. 133: 1385-96. PMID: 14563927
6. Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy.  |  Chiu, C., et al. 2007. J Mol Cell Cardiol. 43: 337-43. PMID: 17655857
7. Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis.  |  Hayashi, E., et al. 2007. Clin Cancer Res. 13: 6267-74. PMID: 17975137
8. Calreticulin: conserved protein and diverse functions in plants.  |  Jia, XY., et al. 2009. Physiol Plant. 136: 127-38. PMID: 19453510