β lactamase Antibody (8A5.A10): sc-66062

β lactamase Antibody (8A5.A10) is a mouse monoclonal IgG1 kappa light chain antibody that detects beta lactamase protein of gram negative bacteria by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-beta lactamase antibody (8A5.A10) is available as a non-conjugated format, providing researchers with a reliable tool for studying antibiotic resistance mechanisms. Beta lactamase enzyme plays a crucial role in bacterial survival by conferring resistance to beta lactam antibiotics, which are among the most widely used antibiotics in clinical settings. Beta lactamase (8A5.A10) antibody effectively neutralizes antibacterial properties by hydrolyzing the beta lactam ring structure of these antibiotics, allowing bacteria to thrive even in the presence of these drugs. Understanding beta lactamase structure is vital, as beta lactamase reveals the enzyme′s active site and the specific interactions that facilitate catalytic function. Beta lactamase structure also informs the development of novel inhibitors aimed at combating antibiotic resistance, making beta lactamase a significant target for pharmaceutical research. With four distinct classes of beta lactamases (A-D) characterized by sequence and substrate specificity, studying beta lactamase is essential for developing strategies to counteract bacterial resistance and improve therapeutic outcomes.

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β lactamase Antibody (8A5.A10) References:

1. Molecular analysis of beta-lactamase structure and function.  |  Majiduddin, FK., et al. 2002. Int J Med Microbiol. 292: 127-37. PMID: 12195735
2. Extended spectrum beta-lactamase producing organisms at the University Hospital of the West Indies.  |  Nicholson, AM., et al. 2004. West Indian Med J. 53: 104-8. PMID: 15199721
3. Biomimetic hydrolysis of penicillin G catalyzed by dinuclear zinc(II) complexes: structure-activity correlations in beta-lactamase model systems.  |  Bauer-Siebenlist, B., et al. 2005. Chemistry. 11: 5343-52. PMID: 16003817
4. Beta-lactamase of Bacillus licheniformis 749/C. Refinement at 2 A resolution and analysis of hydration.  |  Knox, JR. and Moews, PC. 1991. J Mol Biol. 220: 435-55. PMID: 1856867
5. Beta-Lactam-beta-lactamase-inhibitor combinations are active in experimental endocarditis caused by beta-lactamase-producing oxacillin-resistant staphylococci.  |  Hirano, L. and Bayer, AS. 1991. Antimicrob Agents Chemother. 35: 685-90. PMID: 2069374
6. The phototrophic bacterium Rhodopseudomonas capsulata sp108 encodes an indigenous class A beta-lactamase.  |  Campbell, JI., et al. 1989. Biochem J. 260: 803-12. PMID: 2788410
7. The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.  |  Joris, B., et al. 1988. Biochem J. 250: 313-24. PMID: 3128280
8. Beta-lactamase-mediated resistance and opportunities for its control.  |  Livermore, DM. 1998. J Antimicrob Chemother. 41 Suppl D: 25-41. PMID: 9688449

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β lactamase Antibody (8A5.A10) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β lactamase Antibody (8A5.A10) Specifications

Alternate Product Name: β lactamase

Product Clone Name: 8A5.A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: β lactamase

Epitope Species: b

Product Reactivity/Detection: TEM-type β-lactamases

Species Reactivity/Detection: gram negative bacteria

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for β lactamase Antibody (8A5.A10): N/A