AZ628 (CAS 878739-06-1)

外観 :

Powder

身体の状態 :

Solid

溶解度 :

Soluble in DMSO (90 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C).

保存方法 :

Store at -20° C

融点 :

310.98° C (Predicted)

沸騰点 :

710.61° C (Predicted)

密度 :

~1.2 g/cm³ (Predicted)

屈折率 :

n²⁰_D 1.64 (Predicted)

IC50 :

ACN: IC₅₀ = 0.10 nM (human); SH-4: IC₅₀ = 3.01 nM (human); wild-type CRAF: IC₅₀ = 29 nM; BRAFV600E: IC₅₀ = 34 nM; wild-type BRAF: IC₅₀ = 100 nM

pK値 :

pK_a: 12.92 (Predicted), pK_b: 1.78 (Predicted)

WGKドイツ :

3

PubChem CID :

MDL番号 :

MFCD17392577

SMILES :

CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C