Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
5′-AMP-activated protein kinase, known as AMPK, is a heterotrimeric complex that protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Activated AMPK phosphorylates and regulates hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The AMPK-related kinase 5 (ARK5) is a tumor progression-associated factor that is directly phosphorylated by Akt at Ser 600, which is in its regulatory domain. NDR2, a serine/threonine protein kinase, phosphorylates and activates ARK5 during Insulin-like growth factor (IGF)-I signaling in order to promote cell survival. This activation may be involved in the invasion of colorectal cancer cell lines. Furthermore, ARK5 is a transcriptional target of the Large-MAF family and may have a role in mediating the aggressiveness of c-Maf- and MafB-expressing myelomas.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.