Apolipoprotein A I/APOA1 Antibody (2G4): sc-69755
- Apolipoprotein A I/APOA1 Antibody (2G4) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µl
- raised against apoA-I protein of human origin
- recommended for detection of apoA-I of mouse, rat and human origin by WB, IP, IF and ELISA
- See Apolipoprotein A I/APOA1 (B-10): sc-376818 for Apolipoprotein A I/APOA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Apolipoprotein A I/APOA1 Antibody (2G4). This work is in progress.
ApoA-I Antibody (2G4) is a mouse monoclonal IgG1 antibody that detects apoA-I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-apoA-I antibody (2G4) is available in a non-conjugated form, specifically designed for researchers seeking to study apoA-I′s role in lipid metabolism. ApoA-I monoclonal antibody (2G4) recognizes a crucial component of high-density lipoprotein (HDL) in plasma, where apoA-I plays a vital role in promoting cholesterol efflux from peripheral tissues to the liver, facilitating excess cholesterol excretion. This process is essential for maintaining lipid homeostasis and preventing atherosclerosis, making apoA-I a significant target for cardiovascular research. ApoA-I is primarily synthesized in the liver and intestines, and proper functioning is critical for HDL particle formation, which are responsible for transporting cholesterol and other lipids in the bloodstream. Additionally, apoA-I serves as a cofactor for lecithin cholesterol acyltransferase (LCAT), an enzyme that catalyzes the conversion of free cholesterol into cholesteryl esters, further underscoring apoA-I′s importance in lipid metabolism and cardiovascular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Apolipoprotein A I/APOA1 Antibody (2G4) References:
- Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. | Zannis, VI., et al. 2006. J Mol Med (Berl). 84: 276-94. PMID: 16501936
- Significance of Lipid-Free and Lipid-Associated ApoA-I in Cellular Cho-lesterol Efflux. | Dergunov, AD., et al. 2017. Curr Protein Pept Sci. 18: 92-99. PMID: 27412400
- ABCA1, apoA-I, and BTN3A1: A Legitimate Ménage à Trois in Dendritic Cells. | Riganti, C., et al. 2018. Front Immunol. 9: 1246. PMID: 29937767
- Current and Emerging Reconstituted HDL-apoA-I and HDL-apoE Approaches to Treat Atherosclerosis. | Valanti, EK., et al. 2018. J Pers Med. 8: PMID: 30282955
- Relationship between apoA-I, chemerin, Procalcitonin and severity of hyperlipidaemia-induced acute pancreatitis. | Yin, Y., et al. 2022. J Pak Med Assoc. 72: 1201-1204. PMID: 35751336
- Association of serum apoA-I with in-stent restenosis in coronary heart disease. | Wang, X., et al. 2022. BMC Cardiovasc Disord. 22: 355. PMID: 35927634
- The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris. | Vanherle, S., et al. 2022. Cell Rep. 41: 111591. PMID: 36351388
- Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease. | Solé, M., et al. 2023. Br J Pharmacol. 180: 1999-2017. PMID: 36872299
- Microarray analysis identifies human apoA-IMilano and apoA-II as determinants of the liver gene expression related to lipid and energy metabolism. | Ganzetti, GS. and Parolini, C. 2023. Exp Cell Res. 433: 113826. PMID: 37858836
- Predictive value of ApoB/ApoA-I for recurrence within 1 year after first incident stroke. | Lin, J., et al. 2023. Front Neurol. 14: 1308442. PMID: 38274879
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apolipoprotein A I/APOA1 Antibody (2G4) | sc-69755 | 100 µl | $322.00 |