specific for an epitope mapping to a short peptide containing acetylated Serine 1 and Lysine 5, 8 and 12 of Histone H4 of human origin
recommended for detection of Ser 1, Lys 5, Lys 8 and Lys 12 acetylated Histone H4 of broad species and avian origin by WB, IP, IF, IHC(P) and ELISA; 以下追加動物種との反応性もあります： と equine, canine, bovine, porcine and avian
m-IgG Fc BP-HRP and m-IgG2b BP-HRP は推奨セカンダリー検出試薬 Ac-Histone H4 抗体 (F-3) for WB and IHC(P) applications. これらの試薬と Ac-Histone H4 抗体 (F-3) (下記の注文情報をご覧ください)とセットになっています。
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Animal Health Prescription Item
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B, H3 and H4, and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. p300 preferentially acetylates Histone H3 at lysines 14 and 18 and Histone H4 at lysines 5 and 8. PCAF in its native form, primarily acetylates Histone H3 at lysine 14 to a monoacetylated form, and less efficiently acetylates Histone H4 at lysine 8. Histone H4 may also be acetylated at lysines 12 and 16, and the involvement of acetylated H4 with Histones H2A, H2B and H3 suggests that acetylated histones may be involved in dynamic chromatin remodeling.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.