Ac-Histone H4 Antibody (B-10): sc-515319

Ac-Histone H4 Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects Histone H4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Histone H4 antibody (B-10) specifically recognizes acetylated forms of Histone H4, which plays a crucial role in the regulation of gene expression and chromatin dynamics. Histone H4 is a core component of the nucleosome, where it forms a histone octamer with H2A, H2B, and H3, wrapping around approximately 200 base pairs of DNA. This structural arrangement not only compacts DNA into chromatin but also influences the accessibility of transcription factors and other regulatory proteins to DNA, thereby impacting gene transcription. The acetylation of Histone H4, particularly at lysines 5, 8, 12, and 16, is associated with active transcription and chromatin remodeling, making Histone H4 an important marker for studying epigenetic modifications and their effects on gene regulation. Anti-Histone H4 antibody (B-10) enables researchers to gain insights into the dynamic processes of chromatin remodeling and the epigenetic regulation of gene expression in various biological contexts.

The preferred Histone H4 antibody is Histone H4 Antibody (F-9): sc-25260.