7-Hydroxyaristolochic acid A CAS: 79185-75-4
MF: C17H11NO8
MW: 357.27
An aristolochic acid associated with urothelial carcinoma formation.

7-Hydroxyaristolochic acid A (CAS 79185-75-4)

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別名: 6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
アプリケーション: 7-Hydroxyaristolochic acid A is an aristolochic acid associated with urothelial carcinoma formation
CAS 番号: 79185-75-4
Molecular Weight: 357.27
Molecular Formula: C17H11NO8
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* Refer to Certificate of Analysis for lot specific data (including water content).

7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.


参考文献

1. Pfau, W., et al., 1990. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis. 11(9): 1627-33. PMID: 2401053
2. Rossiello, M R., et al., 1993. Induction of hepatic nodules in the rat by aristolochic acid. Cancer letters. 71(1-3): 83-7. PMID: 8364902
3. Mengs, U., et al., 1993. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of toxicology. 67(5): 307-11. PMID: 8368940
4. Hadjiolov, D., et al., 1993. Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. Carcinogenesis. 14(3): 407-10. PMID: 8453716
5. Schmeiser, H H., et al., 1996. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer research. 56(9): 2025-8. PMID: 8616845
6. Levi, M., et al., 1998. Acute hepatitis in a patient using a Chinese herbal tea--a case report. Pharmacy world & science : PWS. 20(1): 43-4. PMID: 9536471
7. Nortier, J L., et al., 2000. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) The New England journal of medicine. 342(23): 1686-92. PMID: 10841870

Physical State :
Solid
Solubility :
Soluble in water.
保存方法 :
Store at -20° C
Melting Point :
287-292° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
COC1=C(C=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O

Download SDS (MSDS)

分析表

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