7-Chlorokynurenic acid sodium salt (CAS 1263094-00-3)
別名:
7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
アプリケーション：
7-Chlorokynurenic acid sodium salt is an NMDA receptor antagonist and inhibitor of EAAT
CAS 番号:
1263094-00-3
Purity:
≥98%
Molecular Weight:
245.60
Molecular Formula:
C10H5CINNaO3
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7-Chlorokynurenic acid sodium salt is an NMDA receptor antagonist acting at the glycine site. 7-Chlorokynurenic acid sodium salt acts as a potent competitive inhibitor of EAAT (L-glutamate transporter) into synaptic vesicles.
参考文献
1. Kemp, J.A., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 6547-6550. PMID: 2842779
2. Kretschmer, B.D., et al. 1995. Eur. J. Pharmacol. 280: 37-45. PMID: 7498252
3. Bartlett, R.D., et al. 1999. Neuropharmacology. 37: 839-846. PMID: 9776380
Physical State
:
Solid
Solubility
:
Soluble in water (100 mM).
保存方法
:
Desiccate at room temperature
Refractive Index
:
n20D 1.65 (Predicted)
IC50
:
Glutamate NMDA receptor: IC50 = 0.32 µM (rat); Glutamate [NMDA] receptor subunit epsilon 4: IC50 = 8 µM (rat); Glutamate [NMDA] receptor subunit 3B: IC50 = 8 µM (rat); Glutamate receptor ionotropic, AMPA 2: IC50 = 153 µM (rat)
Ki Data
:
Vesicular glutamate transporter 3: Ki= 590 µM (rat)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID
:
MDL Number
:
MFCD12195840
SMILES
:
C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)[O-].[Na+]
Download SDS (MSDS)
分析表
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