5,7-Dichloro-8-quinolinol (CAS 773-76-2)

身体の状態 :

Solid

溶解度 :

5% IN DIOXANE; CLEAR TO SLIGHTLY HAZY,YELLOW OR GREEN SOLUTION.Soluble in benzene, acetone. Slightly soluble in acetic acid. Readily soluble in sodium and potassium hydroxides and in acids, forming solutions. Very slightly soluble in: Ethanol Chloroform.

保存方法 :

Store at room temperature

融点 :

178-180° C (lit.)

沸騰点 :

~354.7° C at 760 mmHg (Predicted)

密度 :

~1.5 g/cm³ (Predicted)

屈折率 :

n²⁰_D 1.70 (Predicted)

IC50 :

Arachidonate 5-lipoxygenase: IC₅₀ = 3.6 µM (human); Arachidonate 12-lipoxygenase: IC₅₀ = 1.9 µM (human); Arachidonate 15-lipoxygenase, type II: IC₅₀ = 28 µM (human); Arachidonate 15-lipoxygenase: IC₅₀ = 2.4 µM (human); Kappa opioid receptor: IC₅₀ = 4.56 µM (human); Streptococcus sp. ′group A′: EC₅₀50 = 258 nM (Streptococcus sp. ′group A′); Streptococcus: EC₅₀50 = 3306 nM (Streptococcus); Beta-galactosidase: EC₅₀50 = >31.5 µM (Escherichia coli); Streptokinase A: EC₅₀50 = 148 nM (Streptococcus pyogenes serotype M1); Delta opioid receptor: IC₅₀ >32 µM (human)

pK値 :

pK_a: 2.30, pK_b: 7.20

WGKドイツ :

3

RTECS :

VC5350000

PubChem CID :

Merck 索引 :

14: 2175

MDL番号 :

MFCD00006786

EC番号 :

212-258-3

Beilstein レジストリ :

153606

SMILES :

C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1