![3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile - chemical structure image](https://media.scbt.com/product/3-4-2-fluorobenzoyl-1-methyl-1h-pyrrol-2-yl-2-3-trifluoromethyl-phenyl-2-propenenitrile-structure_22_69_b_226998.jpg)
![3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile - chemical structure image](https://media.scbt.com/product/3-4-2-fluorobenzoyl-1-methyl-1h-pyrrol-2-yl-2-3-trifluoromethyl-phenyl-2-propenenitrile-structure_22_69_t_226998.jpg "Molecular structure of 3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile")
3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile
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Phosphoramidon is an inhibitor of CD10 (neutral endopeptidase 24.11, NEP), metalloproteases (MMPs), and Neprilysin-2 (NEP2), which belong to a group of type II integral membrane glycoproteins. In addition, the NEP enzyme may act to play a role in the regulation of neuropeptide signaling and in the metabolism of bioactive peptides via plasma membranes. NEP2 is a homologue of NEP with a high degree of sequence identity, however, research shows that they have different physiological actions. Studies show that phosphoramidon and thiorphan (sc-201287), another NEP inhibitor, can increase nitrile production. Additionally, LNCaP cell studies show that phosphoramidon can inhibit the metabolism of neurotensin (NT). Phosphoramidon is an inhibitor of endothelial converting enzyme (ECE).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile, 500 mg | sc-310706 | 500 mg | $198.00 | |||
3-[4-(2-Fluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile, 1 g | sc-310706A | 1 g | $269.00 |