2-Furoyl-LIGRLO-amide trifluoroacetate salt CAS: 729589-58-6 (non-salt)
MF: C36H63N11O8 xC2HF3O2
MW: 777.95 (free base)
A potent, selective PAR2 agonist.

2-Furoyl-LIGRLO-amide trifluoroacetate salt (CAS 729589-58-6 (non-salt))

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別名: 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt; 2-fAP; 2-Fly
アプリケーション: 2-Furoyl-LIGRLO-amide trifluoroacetate salt is a potent, selective PAR2 agonist
CAS 番号: 729589-58-6 (non-salt)
Molecular Weight: 777.95 (free base)
Molecular Formula: C36H63N11O8 xC2HF3O2
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed, increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation.


参考文献

Gardell, L.R., et al., Identification and characterization of novel small molecule protease activated receptor 2 (PAR2) agonists. J. Pharmacol. Exp. Ther., (2008); Hollenberg, M.D., et al., Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. J. Pharmacol. Exp. Ther. 326, 453-462, (2008); Niu, Q.X., et al., Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2. Clin. Exp. Pharmacol. Physiol. 35, 89-96, (2008)

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in water (>2 mg/ml).
保存方法 :
Store at -20° C
Refractive Index :
n20D 1.61 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
MDL Number :
MFCD03821022

Download SDS (MSDS)

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