Molecular structure of 2,4′-Dibromoacetophenone
2,4′-Dibromoacetophenone (CAS 99-73-0)
Alternate Names:
alpha,4-Dibromoacetophenone, 4-Bromophenacyl bromide
CAS Number:
99-73-0
Purity:
≥98%
Molecular Weight:
277.95
Molecular Formula:
C8H6Br2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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GSK-3beta Inhibitor VII is a phenyl alpha-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3beta) (IC = 0.5 muM). This compound acts as an alkylating agent that is selective towards GSK-3beta and does not affect PKA activity even at concentrations as high as 100 muM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.
2,4′-Dibromoacetophenone (CAS 99-73-0) References
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- Preparation and purification of soybean lipoxygenase-derived unsaturated hydroperoxy and hydroxy fatty acids and determination of molar absorptivities of hydroxy fatty acids. | Graff, G., et al. 1990. Anal Biochem. 188: 38-47. PMID: 2121063
- The role of arachidonic acid release and lipoxygenase pathway in lipopolysaccharide-induced thromboplastin activity in monocytes. | Osterud, B., et al. 1990. Blood Coagul Fibrinolysis. 1: 41-6. PMID: 2129391
- Spectroscopic characterization, antioxidant and antitumour studies of novel bromo substituted thiosemicarbazone and its copper(II), nickel(II) and palladium(II) complexes. | Jagadeesh, M., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 135: 180-4. PMID: 25064500
- Biotransformation of acetophenone and its halogen derivatives by Yarrowia lipolytica strains. | Janeczko, T., et al. 2015. Ann Microbiol. 65: 1097-1107. PMID: 26005401
- A new derivatization method for the determination of valproic acid in serum using tetramethylammonium hydroxide as a catalyst. | Mao, G., et al. 2019. Biomed Chromatogr. 33: e4440. PMID: 30456910
- Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC. | Pourasghar, M., et al. 2019. J Pharm Anal. 9: 100-107. PMID: 31011466
- Clinical pharmacology of sodium butyrate in patients with acute leukemia. | Miller, AA., et al. 1987. Eur J Cancer Clin Oncol. 23: 1283-7. PMID: 3678322
- In-vitro contractility of rat seminiferous tubules in response to prostaglandins, cyclic GMP, testosterone and 2,4'-dibromoacetophenone. | Farr, CH. and Ellis, LC. 1980. J Reprod Fertil. 58: 37-42. PMID: 6244406
- Adenosine stimulation of DNA synthesis in human endothelial cells. | Ethier, MF. and Dobson, JG. 1997. Am J Physiol. 272: H1470-9. PMID: 9087626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,4′-Dibromoacetophenone, 1 g | sc-506187B | 1 g | $15.00 | |||
2,4′-Dibromoacetophenone, 25 g | sc-506187 | 25 g | $124.00 | |||
2,4′-Dibromoacetophenone, 100 g | sc-506187A | 100 g | $416.00 | |||
2,4′-Dibromoacetophenone, 500 g | sc-506187C | 500 g | $1873.00 |