15-keto Fluprostenol isopropyl ester (CAS 404830-45-1)
QUICK LINKS
An F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals and is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.3 The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.
15-keto Fluprostenol isopropyl ester (CAS 404830-45-1) References
- Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. | Hellberg, MR., et al. 2001. J Ocul Pharmacol Ther. 17: 421-32. PMID: 11765147
- Effect of Fluprostenol Isopropyl Ester and 15-Keto Fluprostenol on Eyelash Growth: A Clinical and Pharmacologic Study. | Ciro, C. and Luigi, P. 2018. Skinmed. 16: 231-233. PMID: 30207524
- 15 keto fluprostenol isopropyl ester (80 µgr/mL) gel for cosmetic eyelash growth and enhancement. | Fabbrocini, G., et al. 2019. J Cosmet Dermatol. 18: 545-549. PMID: 30664828
- Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes. | Hutchison, DM., et al. 2022. J Eur Acad Dermatol Venereol. 36: 536-546. PMID: 34919300
- Trends in development and quality assessment of pharmaceutical formulations - F2α analogues in the glaucoma treatment. | Asendrych-Wicik, K., et al. 2023. Eur J Pharm Sci. 180: 106315. PMID: 36367507
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-keto Fluprostenol isopropyl ester, 1 mg | sc-220621 | 1 mg | $84.00 | |||
15-keto Fluprostenol isopropyl ester, 5 mg | sc-220621A | 5 mg | $380.00 |