Nup133 Activators
The chemical class of Nup133 activators encompasses a diverse range of compounds that indirectly influence the function and regulation of the Nucleoporin NUP133, a key component of the nuclear pore complex (NPC). These chemicals exert their effects through various pathways and cellular processes, ultimately modulating the activity or assembly of the NPC, where NUP133 plays a pivotal role.
These chemicals interact with cellular components and processes that are indirectly linked to NUP133's function. Compounds like Phosphatidylinositol 4,5-bisphosphate (PIP2) and Guanosine Triphosphate (GTP) are crucial for the structural and functional integrity of NPCs. PIP2 regulates membrane dynamics that are essential for NPC assembly, while GTP is involved in the Ran-GTPase cycle, a key regulator of nucleocytoplasmic transport. Similarly, Adenosine Triphosphate (ATP) provides the necessary energy for transport mechanisms involving the NPC. Other compounds, such as Brefeldin A and Leptomycin B, modulate various aspects of nucleocytoplasmic transport and thereby influence NUP133 indirectly. These activators affect the physical and biochemical environment of NUP133. Cytochalasins and jasplakinolide, through their action on the cytoskeleton, influence the mechanical properties of the nuclear envelope, impacting NPC assembly and function. Nocodazole and Taxol, which target microtubules, alter intracellular transport dynamics, thereby affecting NPC-related processes. Additionally, compounds like Lithium Chloride, Forskolin, and Rapamycin modulate various signaling pathways such as GSK-3, cAMP, and mTOR pathways. These signaling pathways play a role in cellular processes like metabolism and transport, indirectly influencing the role of NUP133 in the NPC.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-triphosphate trisodium salt | 36051-31-7 | sc-215111 sc-215111A | 10 mg 25 mg | $46.00 $71.00 | ||
GTP is essential for the GTPase activity of Ran, a small GTPase involved in nuclear transport. Ran-GTP gradients are crucial for nucleocytoplasmic transport, indirectly affecting NUP133's function in the nuclear pore complex. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP is necessary for the energy-dependent steps of nuclear transport. It powers the transport receptors that interact with nuclear pore complexes, including NUP133, facilitating the translocation of cargo. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts the Golgi apparatus and indirectly affects nucleocytoplasmic transport by modulating the cellular localization and recycling of transport receptors, thereby influencing NUP133 activity. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and indirectly affects the mechanical forces exerted on the nuclear envelope, which can influence the assembly and function of nuclear pore complexes including NUP133. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization, affecting cytoskeletal dynamics. This indirectly impacts the mechanical stability of the nuclear envelope and nuclear pore complexes, thereby influencing NUP133. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Interferes with microtubule polymerization, affecting intracellular transport and cellular architecture. This can indirectly influence NUP133's function in nuclear pore complex assembly and maintenance. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and affects cellular transport processes. By altering intracellular transport dynamics, Taxol can indirectly influence the function of NUP133 in the nuclear pore complex. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Affects glycogen synthase kinase-3 (GSK-3) signaling, which is implicated in various cellular processes including transport. This can indirectly modulate NUP133's function in nuclear pore complexes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can modulate various cellular processes, potentially affecting NUP133's role in the nuclear pore complex. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, a key regulator of cell growth and metabolism. By modulating cellular metabolic status, Rapamycin can indirectly influence NUP133's function in the nuclear pore complex. | ||||||