Molecular structure of V-PYRRO/NO, CAS Number: 179344-98-0
V-PYRRO/NO (CAS 179344-98-0)
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Application:
V-PYRRO/NO is a nitric oxide donor
CAS Number:
179344-98-0
Molecular Weight:
157.17
Molecular Formula:
C6H11N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
V-PYRRO/NO is a nitric oxide (NO) donor under physiological conditions. Following hepatic metabolism, it spontaneously decomposes to liberate NO with a half-life of 3 seconds.
V-PYRRO/NO (CAS 179344-98-0) References
- V-PYRRO/NO: an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion. | Ricciardi, R., et al. 2001. Transplantation. 71: 193-8. PMID: 11213058
- The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. | Liu, J., et al. 2003. Hepatology. 37: 324-33. PMID: 12540782
- The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice. | Li, C., et al. 2003. Toxicology. 189: 173-80. PMID: 12832150
- Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO. | Liu, J. and Waalkes, MP. 2005. Toxicology. 208: 289-97. PMID: 15691592
- The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet. | Maslak, E., et al. 2015. Biochem Pharmacol. 93: 389-400. PMID: 25534988
- Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics. | Kus, K., et al. 2015. Drug Metab Dispos. 43: 1028-36. PMID: 25870102
- V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-κB activation pathway. | Hong, FF., et al. 2016. Biomed Rep. 4: 112-116. PMID: 26870346
- Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLI/NO. | Kus, K., et al. 2017. Pharmacol Rep. 69: 560-565. PMID: 28364696
- Short-term treatment with hepatoselective NO donor V-PYRRO/NO improves blood flow in hepatic microcirculation in liver steatosis in mice. | Kus, E., et al. 2018. Pharmacol Rep. 70: 463-469. PMID: 29631249
- Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. | Saavedra, JE., et al. 1997. J Med Chem. 40: 1947-54. PMID: 9207935
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
V-PYRRO/NO, 5 mg | sc-205538 | 5 mg | $34.00 | |||
V-PYRRO/NO, 10 mg | sc-205538A | 10 mg | $60.00 |