Unc18-2 Antibody (D-2): sc-390864

Unc18-2 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects Unc18-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Unc18-2 plays a crucial role in the regulation of exocytosis by acting as a chaperone that binds to syntaxin proteins, thereby preventing their premature interactions with soluble NSF attachment protein receptors. This interaction is vital for the proper functioning of synaptic transmission and hormone secretion, making Unc18-2 essential for various physiological processes. Unc18-2 is predominantly localized at the apical plasma membrane of epithelial cells in the intestine, proximal tubule, and collecting duct, where Unc18-2 co-localizes with Syntaxin 3. This specific localization is important as it facilitates the precise regulation of vesicle trafficking and secretion in these tissues, ensuring that cellular communication and nutrient absorption occur efficiently. Anti-Unc18-2 antibody (D-2) is an invaluable tool for researchers studying the mechanisms of exocytosis and the role of syntaxin binding proteins in cellular function.

The preferred Unc18-2 antibody is Unc18-2 Antibody (B-2): sc-376639.