Trk C Antibody (WW6): sc-80403
- Trk C Antibody (WW6) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 100 µg/ml
- raised against an extracellular domain of Trk C of human origin
- recommended for detection of Trk C of human origin by WB, IF and IHC(P); non cross-reactive with Trk B
- See Trk (B-3): sc-7268 for Trk C antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Trk C Antibody (WW6). This work is in progress.
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Trk C Antibody (WW6) is a mouse monoclonal IgG2b antibody that detects Trk C in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Trk C, a member of the tropomyosin receptor kinase family, plays a crucial role in the nervous system by serving as a functional receptor for neurotrophin-3 (NT-3), which is essential for the survival and differentiation of neurons. Anti-Trk C antibody (WW6) helps researchers study neurotrophic signaling, which influences neuronal development and plasticity. Notably, Trk C is primarily expressed in nervous tissue, and various isoforms, produced through alternative splicing, exhibit distinct structural features that may affect their functional roles in neurotrophic signaling pathways. For instance, isoform A is the full-length version, while isoforms B, C, and D have specific deletions that could potentially alter their interaction with NT-3 and other signaling molecules. Trk C monoclonal antibody (WW6) enables researchers to gain insights into the mechanisms of neurotrophic signaling and its implications in neurodevelopmental and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Trk C Antibody (WW6) References:
- Trk C signaling is required for retinal progenitor cell proliferation. | Das, I., et al. 2000. J Neurosci. 20: 2887-95. PMID: 10751441
- Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. | Lin, MI., et al. 2000. Dev Biol. 226: 180-91. PMID: 11023679
- Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease. | Savaskan, E., et al. 2000. Eur Neurol. 44: 172-80. PMID: 11053967
- NGF, NT-3 and Trk C mRNAs, but not TrkA mRNA, are upregulated in the paraventricular structures in experimental hydrocephalus. | Shinoda, M., et al. 2001. Childs Nerv Syst. 17: 704-12. PMID: 11862435
- Rat cerebral endothelial cells express trk C and are regulated by neurotrophin-3. | Takeo, C., et al. 2003. Biochem Biophys Res Commun. 305: 400-6. PMID: 12745089
- Expression of neurotrophin receptor Trk-C in nevi and melanomas. | Xu, X., et al. 2003. J Cutan Pathol. 30: 318-22. PMID: 12753172
- Developmental regulation of neurotrophin-3 and trk C splice variants in optic nerve glia in vivo. | Elkabes, S., et al. 1995. Neuroscience. 66: 879-89. PMID: 7651615
- Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis. | Duberley, RM., et al. 1997. J Neurol Sci. 148: 33-40. PMID: 9125388
- Expression and function of Trk-C in favourable human neuroblastomas. | Yamashiro, DJ., et al. 1997. Eur J Cancer. 33: 2054-7. PMID: 9516852
- Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma. | Svensson, T., et al. 1997. Eur J Cancer. 33: 2058-63. PMID: 9580079
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trk C Antibody (WW6) | sc-80403 | 100 µg/ml | $322.00 |