TNF-R1 Antibody (H398): sc-52739

TNF-R1 Antibody (H398) is a mouse monoclonal IgG2a antibody that detects tumor necrosis factor receptor 1 (TNF-R1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TNF-R1 plays a crucial role in mediating the effects of tumor necrosis factor, a key cytokine involved in inflammation and immune responses. TNF-R1 is primarily located on the surface of various cell types, including immune cells, where TNF-R1 initiates signaling pathways that can lead to cell survival, proliferation, or apoptosis, depending on the context. TNF-R1′s ability to transduce apoptotic signals is particularly important, as TNF-R1 helps regulate programmed cell death, which is essential for maintaining tissue homeostasis and immune system function. Dysregulation of TNF-R1 signaling has been implicated in numerous diseases, including autoimmune disorders and cancer, making TNF-R1 a significant target for therapeutic intervention. Anti-TNF-R1 antibody (H398) is an invaluable tool for researchers studying these pathways and their implications in health and disease.

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TNF-R1 Antibody (H398) References:

1. TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.  |  Mace, KE., et al. 2010. J Cell Physiol. 225: 444-53. PMID: 20458742
2. TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface.  |  Terry Powers, JL., et al. 2010. Biochemistry. 49: 7821-9. PMID: 20704259
3. TNF-α (-308G>A) and TNF-R1 (36A>G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development.  |  Ilic, B., et al. 2017. J Oral Pathol Med. 46: 292-296. PMID: 28199753
4. Role of ubiquitination and proteolysis in the regulation of pro- and anti-apoptotic TNF-R1 signaling.  |  Fritsch, J., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 2138-2146. PMID: 28765050
5. VEGF-R2 and TNF-R1 expression and cytokine production by samples of mammary adenocarcinomas and correlations with histopathological parameters of these malignant tumors.  |  Autenshlyus, A., et al. 2018. Int J Immunopathol Pharmacol. 32: 2058738418787990. PMID: 29985074
6. Kupffer Cell-Derived TNF-α Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress.  |  Wang, WM., et al. 2020. Biomed Res Int. 2020: 8035671. PMID: 32802876
7. NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline.  |  Delaby, C., et al. 2021. Sci Rep. 11: 10283. PMID: 33986423
8. Predictive Role of Soluble IL-6R, TNF-R1/2, and Cell Adhesion Molecules Serum Levels in the Preoperative and Adjuvant Therapy in Women with Nonmetastatic Breast Cancer: A Preliminary Study.  |  Bulska-Będkowska, W., et al. 2022. J Interferon Cytokine Res.. PMID: 36130158
9. Elevated plasma levels of TNF-R1 predict the development of acute ischemic events in coronary patients with diabetes.  |  Mas-Fontao, S., et al. 2024. Clin Investig Arterioscler.. PMID: 39343690
10. (-)-Epigallocatechin-3-gallate (EGCG) ameliorates ovalbumin-induced asthma by inhibiting inflammation via the TNF-α/TNF-R1/NLRP3 signaling pathway.  |  Zhang, B., et al. 2025. Int Immunopharmacol. 144: 113708. PMID: 39626539

The preferred TNF-R1 antibody is TNF-R1 Antibody (H-5): sc-8436.