TNF-R1 Antibody (E-11): sc-374186

TNF-R1 Antibody (E-11) is a mouse monoclonal IgG2b antibody that detects TNF-R1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TNF-R1, a critical component of the immune response, is primarily located on the surface of most cell types, where TNF-R1 plays a pivotal role in mediating the effects of tumor necrosis factor, a key cytokine involved in inflammation and apoptosis. TNF-R1′s presence on diverse cell types allows for a wide range of biological responses, including cell survival, proliferation, and differentiation, making TNF-R1 essential for maintaining immune homeostasis. TNF-R1 interacts with several signaling proteins, including TRADD, FADD, and RIP, which are crucial for propagating apoptotic signals within the cell. TNF-R1′s ability to initiate apoptosis through its "death domain" motif underscores TNF-R1′s significance in regulating cell fate and highlights TNF-R1′s potential as a therapeutic target in diseases characterized by dysregulated apoptosis, such as cancer and autoimmune disorders. Anti-TNF-R1 antibody (E-11) is an invaluable tool for researchers investigating the complex roles of TNF signaling in health and disease.

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TNF-R1 Antibody (E-11) References:

1. Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes.  |  Yin, XM. 2000. J Mol Med (Berl). 78: 203-11. PMID: 10933582
2. The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.  |  Filippova, M., et al. 2002. J Biol Chem. 277: 21730-9. PMID: 11934887
3. Enhanced expression of TNF-R1 protein in NMDA-mediated cell death in the retina.  |  Laabich, A., et al. 2002. Brain Res Mol Brain Res. 109: 239-46. PMID: 12531535
4. Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes.  |  Lozano, JM., et al. 2003. Scand J Gastroenterol. 38: 1169-75. PMID: 14686721
5. Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells.  |  Rodriguez, DA., et al. 2004. Alcohol. 33: 9-15. PMID: 15353169
6. Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites.  |  Van Linden, AA., et al. 2005. Biochemistry. 44: 6980-9. PMID: 15865443
7. New perspectives in TNF-R1-induced NF-κB signaling.  |  Gentle, IE. and Silke, J. 2011. Adv Exp Med Biol. 691: 79-88. PMID: 21153311
8. Soluble TNF-R1, VEGF and other cytokines as markers of disease activity in systemic lupus erythematosus and lupus nephritis.  |  Adhya, Z., et al. 2019. Lupus. 28: 713-721. PMID: 31046570
9. Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer.  |  Wang, SC., et al. 2021. Cancers (Basel). 13: PMID: 34439091
10. Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production.  |  Wang, X., et al. 2022. J Microbiol Biotechnol. 32: 348-354. PMID: 35001008

The preferred TNF-R1 antibody is TNF-R1 Antibody (H-5): sc-8436.