TLR9 Antibody (F-3): sc-515921

TLR9 Antibody (F-3) is a mouse monoclonal IgM kappa antibody that detects TLR9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TLR9 antibody (F-3) is available as the non-conjugated format. TLR9 protein plays a crucial role in the innate immune system by recognizing unmethylated CpG motifs commonly found in bacterial and viral DNA, which is essential for initiating an immune response. Upon activation, TLR9 triggers signaling pathways that lead to the production of pro-inflammatory cytokines and type I interferons, thereby enhancing the host′s ability to combat infections. This function is particularly important in pathogen recognition and subsequent activation of adaptive immunity, making TLR9 a key player in the body′s defense mechanisms. TLR family, including TLR9, is characterized by a highly conserved Toll homology domain vital for signal transduction, and TLR9 is predominantly expressed in immune-related tissues such as spleen, lymph nodes, and bone marrow, underscoring its significance in immune surveillance and response.

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TLR9 Antibody (F-3) References:

1. Understanding TLR9 action in Epstein-Barr virus infection.  |  Zauner, L. and Nadal, D. 2012. Front Biosci (Landmark Ed). 17: 1219-31. PMID: 22201799
2. Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes.  |  Ward, GA., et al. 2023. Int J Mol Sci. 24: PMID: 36835307
3. Targeted TLR9 Agonist Elicits Effective Antitumor Immunity against Spontaneously Arising Breast Tumors.  |  Miller, CL., et al. 2023. J Immunol. 211: 295-305. PMID: 37256255
4. Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma.  |  Cascini, C., et al. 2023. J Exp Clin Cancer Res. 42: 154. PMID: 37365634
5. TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development.  |  Miles, MA., et al. 2024. Cells. 13: PMID: 38201300
6. TLR9 Knockdown Alleviates Sepsis via Disruption of MyD88/NF-κB Pathway Activation.  |  Li, L., et al. 2024. Crit Rev Immunol. 44: 15-24. PMID: 38305333
7. Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection.  |  Kim, J., et al. 2024. bioRxiv.. PMID: 38496452
8. Dendritic Cell - Fibroblast Crosstalk via TLR9 and AHR Signaling Drives Lung Fibrogenesis.  |  Carter, H., et al. 2024. bioRxiv.. PMID: 38559175
9. TLR9 mediates IgA production in the porcine small intestine during PEDV infection.  |  Wang, C., et al. 2024. Vet Microbiol. 293: 110096. PMID: 38636174
10. Characterization of the TLR9-Activating Potential of LNA-Modified Antisense Oligonucleotides.  |  Riera-Tur, I., et al. 2024. Nucleic Acid Ther. 34: 257-271. PMID: 39018509

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR9 Antibody (F-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR9 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR9 Antibody (F-3) Specifications

Alternate Product Name: TLR9

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1007-1032

Epitope Target: TLR9

Epitope Species: human

Product Reactivity/Detection: TLR9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TLR9 Antibody (F-3): N/A

The preferred TLR9 antibody is TLR9 Antibody (E-9): sc-518138.