TLR Attivatori per le analisi funzionali delle risposte cellulari a TLR
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TLR7 Antibody (4F4) is a high quality monoclonal TLR7 antibody (also designated TLR7 antibody) suitable for the detection of the TLR7 protein of human origin. TLR7 Antibody (4F4) is available as the non-conjugated anti-TLR7 antibody. The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFκB signaling pathway, suggesting that they play a role in the immune response.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Seria possível dizerem-me qual a sequência do imunógeno?
Richiesta da: PinhoP
Thank you for your question. This antibody was raised against amino acids 451-500 of TLR7 of human origin. The exact epitope has not been mapped, so no further information is available.
Risposta da: Tech Service
Data di pubblicazione: 2020-02-05
I am using TLR7 (4F4): sc-57463 for immunofluorescence, what dilution of this antibody should I use?
Richiesta da: jenni
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here:
Rated 1 di
Zeigt leider eine unspezifische BandeAn mit verschiedenen TLRs stabil transduzierten HEK-Zell-Kulturen getestet. Zeigt leider in allen Lysaten eine Bande, nicht nur bei TLR7.
Data di pubblicazione: 2018-05-30
Rated 5 di
Susanne M da
Gute Ergebnisse ImmunfluoreszenzHabe verschiedene Tumor-Zelllinien getestet und der AK hat super funktioniert.
Data di pubblicazione: 2017-12-15
Rated 5 di
We found the product working extremely wellWe found the product working extremely well on cervical tissue and would recommend others working on human tissue to use the antibody.
Data di pubblicazione: 2015-11-11
Rated 3 di
Signal via western blot analysis of TLR7Signal via western blot analysis of TLR7 expression in Ramos whole cell lysate. -SCBT QC
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