Anti-TCF-3 Antibody E-2 è un monoclonale di topo IgG1 κ TCF-3 antibody, citato in 5 pubblicazioni, fornito in 200 µg/ml
specifico per un epitopo mappato tra gli amminoacidi 97-126 vicino al N-terminus di TCF-3 di origine mouse
TCF-3 Antibody (E-2) é raccomandato per il rilevamento di TCF-3 di origine mouse, rat e human in WB, IP, IF e ELISA
TCF-3 Antibody (E-2) é disponibile coniugato con agarose per IP; HRP per WB, IHC(P) ed ELISA; sia con phycoerythrin o FITC per IF, IHC(P) e FCM
disponibile anche coniugato con Alexa Fluor® 488, Alexa Fluor® 546; Alexa Fluor® 594 o Alexa Fluor® 647 per IF, IHC (P) e FCM
disponibile anche coniugato con Alexa Fluor® 680 o Alexa Fluor® 790 per WB (NIR), IF e FCM
reagente TransCruz per utilizzo in Gel Supershift e ChIP (sc-166411 X, 200 µg/0.1 ml)
Contattaci per ricevere un FREE 10 µg sample di TCF-3 (E-2): sc-166411.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TCF-3 Antibody (E-2) for WB applications. These reagents are now offered in bundles with TCF-3 Antibody (E-2) (see ordering information below).
TCF Inibitori per le analisi funzionali delle risposte cellulari a TCF
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TCF-3 Antibody (E-2) is a high quality monoclonal TCF-3 antibody (also designated TCF3 antibody, TCF7L1 antibody, or transcription factor 7 like 1 antibody) suitable for the detection of the TCF-3 protein of mouse, rat and human origin. TCF-3 Antibody (E-2) is available as both the non-conjugated anti-TCF-3 antibody form, as well as multiple conjugated forms of anti-TCF-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The TCF/LEF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. The TCF (T cell factor) proteins are required during developmental pathways. TCF-1 is essential for lymphoid cell development, while two other members, TCF-3 and TCF-4, are implicated in the development of the central nervous system. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin to, thereby, inhibit the activity of TCF proteins. Mutations in the APC gene, which are commonly observed in colorectal carcinomas, disrupt this regulatory pathway and correlate with an accumulation of β-catenin and the increased activation of the TCF target genes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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