SNAT4 Antibody (H-9): sc-376664

SNAT4 Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNAT4 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SNAT4 (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The sodium-coupled neutral amino acid transporter SNAT4, also known as ATA3, NAT3, or PAAT, is a member of the SLC38 gene family, which plays a crucial role in the transport of essential nutrients across cell membranes. SNAT4 is primarily located in the liver, where SNAT4 facilitates the uptake of neutral amino acids, which are vital for protein synthesis and metabolic processes. SNAT4 function is particularly important during fetal development, as SNAT4 supports the nutritional needs of the developing fetus; disruptions in SNAT4 activity have been linked to fetal growth retardation. SNAT4 is also expressed to a lesser extent in tissues such as muscle, kidney, and pancreas, highlighting SNAT4′s diverse physiological roles. SNAT4′s ability to transport amino acids efficiently underscores SNAT4′s significance in energy production, metabolism, and neurotransmitter cycling, making anti-SNAT4 antibody (H-9) an essential tool for researchers studying these critical biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SNAT4 Antibody (H-9) References:

1. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.  |  Wang, H., et al. 2000. Biochem Biophys Res Commun. 273: 1175-9. PMID: 10891391
2. Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.  |  Hatanaka, T., et al. 2000. Biochim Biophys Acta. 1467: 1-6. PMID: 10930503
3. Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.  |  Gu, S., et al. 2001. J Biol Chem. 276: 24137-44. PMID: 11325958
4. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization.  |  Gu, S., et al. 2001. Genomics. 74: 262-72. PMID: 11414754
5. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane.  |  Freeman, TL., et al. 2002. Arch Biochem Biophys. 400: 215-22. PMID: 12054432
6. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.  |  Palii, SS., et al. 2004. J Biol Chem. 279: 3463-71. PMID: 14623874
7. Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.  |  Sidoryk, M., et al. 2004. Neuroreport. 15: 575-8. PMID: 15094455
8. SNAT4 isoform of system A amino acid transporter is expressed in human placenta.  |  Desforges, M., et al. 2006. Am J Physiol Cell Physiol. 290: C305-12. PMID: 16148032
9. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane.  |  Desforges, M., et al. 2009. J Physiol. 587: 61-72. PMID: 19015196
10. Residue cysteine 232 is important for substrate transport of neutral amino acid transporter, SNAT4.  |  Padmanabhan, R., et al. 2012. Int J Biochem Mol Biol. 3: 374-83. PMID: 23301202
11. Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter.  |  Padmanabhan Iyer, R., et al. 2013. PLoS One. 8: e56792. PMID: 23451088
12. [18F]-C-SNAT4: an improved caspase-3-sensitive nanoaggregation PET tracer for imaging of tumor responses to chemo- and immunotherapies.  |  Chen, M., et al. 2021. Eur J Nucl Med Mol Imaging. 48: 3386-3399. PMID: 33712870

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAT4 Antibody (H-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAT4 Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAT4 Antibody (H-9) Specifications

Alternate Product Name: SNAT4

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-60

Epitope Target: SNAT4

Epitope Species: mouse

Product Reactivity/Detection: SNAT4

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SNAT4 Antibody (H-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin