Molecular structure of SK&F 97541, CAS Number: 127729-35-5
SK&F 97541 (CAS 127729-35-5)
Alternate Names:
3-aminopropyl(methyl)phosphinic acid
Application:
SK&F 97541 is a very potent GABAB agonist/GABAC antagonist
CAS Number:
127729-35-5
Purity:
98%
Molecular Weight:
137.1
Molecular Formula:
C4H12NO2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SK&F 97541 is a very potent GABAB agonist, at least ten times more active than baclofen. It is also known to act as a GABAC antagonist. It evokes concentration-dependent hyperpolarization and depresses excitatory postsynaptic potentials. SK&F 97541 is an inhibitor of GABAA R rho 1.
SK&F 97541 (CAS 127729-35-5) References
- Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. | Martin, SC., et al. 1999. Mol Cell Neurosci. 13: 180-91. PMID: 10328880
- Subpopulations of GABA-mediated synaptic potentials in slices of rat dorsal striatum are differentially modulated by presynaptic GABAB receptors. | Seabrook, GR., et al. 1991. Brain Res. 562: 332-4. PMID: 1663417
- Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors. | Zhang, J., et al. 2008. Mol Pharmacol. 74: 941-51. PMID: 18599601
- Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. | Seabrook, GR., et al. 1990. Br J Pharmacol. 101: 949-57. PMID: 1964824
- Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation. | Lehmann, A., et al. 2012. Br J Pharmacol. 165: 1757-1772. PMID: 21950457
- Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. | Froestl, W., et al. 1995. J Med Chem. 38: 3297-312. PMID: 7650684
- Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. | Pan, ZH. and Lipton, SA. 1995. J Neurosci. 15: 2668-79. PMID: 7722621
- Phosphinic acid derivatives as baclofen agonists and antagonists in the mammalian spinal cord: an in vivo study. | Lacey, G. and Curtis, DR. 1994. Exp Brain Res. 101: 59-72. PMID: 7843303
- Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro. | Bon, C. and Galvan, M. 1996. Br J Pharmacol. 118: 961-7. PMID: 8799569
- Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes. | Santos, AE., et al. 1995. Neurochem Int. 27: 397-406. PMID: 8845740
- Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist. | Ragozzino, D., et al. 1996. Mol Pharmacol. 50: 1024-30. PMID: 8863850
- GABAc receptors: relatively simple transmitter -gated ion channels? | Johnston, GA. 1996. Trends Pharmacol Sci. 17: 319-23. PMID: 8885697
Inhibitor of:
GABAA R rho 1.Activator of:
GABA Receptor, and GABAC Rρ1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SK&F 97541, 5 mg | sc-200469 | 5 mg | $101.00 | |||
SK&F 97541, 25 mg | sc-200469A | 25 mg | $450.00 |