Six2 Antibody (NB-A37): sc-135560
- Six2 Antibody (NB-A37) is a mouse monoclonal mouse IgG1 κ κ provided at 100 µg/ml
- raised against recombinant Six2 protein of human origin
- recommended for detection of Six2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Six2 Antibody (NB-A37). This work is in progress.
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Six2 Antibody (NB-A37) is a mouse monoclonal IgG1 antibody that detects Six2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Six2 monoclonal antibody (NB-A37) recognizes a member of the Six family of homeodomain transcription factors, which play a crucial role in regulating gene expression during development and tissue differentiation. Six2 is primarily located in the nucleus, where Six2 binds to specific DNA sequences to modulate the transcription of target genes, making Six2 essential for proper organogenesis and cellular function. Notably, Six2 (NB-A37) antibody detects high expression in fetal tissues, indicating Six2′s importance in developmental processes, while expression is significantly reduced in adult tissues, suggesting a tightly regulated role that may be disrupted in pathological conditions. Dysregulation of Six2 has been implicated in various cancers, highlighting Six2′s potential as a biomarker for tumorigenesis and a target for therapeutic intervention. Anti-Six2 antibody (NB-A37) serves as an invaluable tool for researchers investigating this transcription factor in development and disease.
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Six2 Antibody (NB-A37) References:
- SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor. | Murphy, AJ., et al. 2012. J Pediatr Surg. 47: 1239-49. PMID: 22703800
- Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis. | Liu, J., et al. 2016. Int J Mol Sci. 17: PMID: 27618015
- Six2 is involved in GATA1-mediated cell apoptosis in mouse embryonic kidney-derived cell lines. | Xia, H., et al. 2017. In Vitro Cell Dev Biol Anim. 53: 827-833. PMID: 28842839
- Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. | Sweat, YY., et al. 2020. Dev Biol. 458: 246-256. PMID: 31765609
- Generation and characterization of Six2 conditional mice. | Li, C., et al. 2020. Genesis. 58: e23365. PMID: 32277572
- SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. | Bevacqua, RJ., et al. 2021. Genes Dev. 35: 234-249. PMID: 33446570
- Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation. | Xu, J., et al. 2022. Front Cell Dev Biol. 10: 815249. PMID: 35178390
- SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer. | Leppänen, N., et al. 2024. Nucleic Acids Res. 52: 5610-5623. PMID: 38554106
- Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression. | Cao, XY., et al. 2024. Brain Res Bull. 212: 110970. PMID: 38688414
- The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells. | Guo, Q., et al. 2024. J Transl Med. 22: 832. PMID: 39256760
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Six2 Antibody (NB-A37) | sc-135560 | 100 µg/ml | $339.00 |