Septin 5 Antibody (E-10): sc-373903

Septin 5 Antibody (E-10) is a mouse monoclonal IgM antibody that detects Septin 5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Septin 5 plays a crucial role in the organization of the cytoskeleton and is involved in various cellular processes, including cytokinesis and the regulation of exocytosis. Septin 5 is primarily localized to the cytoplasm, where Septin 5 forms heteropolymer complexes with other septins, contributing to the structural integrity of the cytoskeleton and facilitating cellular division. Proper localization and function of Septin 5 are vital for maintaining cellular architecture and ensuring successful cell division, as disruptions in septin function can lead to various diseases, including cancer. Septin 5 has been implicated in neurodegenerative disorders, highlighting Septin 5′s importance in both normal cellular function and disease pathology. Anti-Septin 5 antibody (E-10) is an essential tool for researchers studying these critical processes and the underlying mechanisms of related diseases.

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Septin 5 Antibody (E-10) References:

1. Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry.  |  Katagiri, T., et al. 2010. Proteome Sci. 8: 41. PMID: 20659346
2. Synaptic protein deficits are associated with dementia irrespective of extreme old age.  |  Beeri, MS., et al. 2012. Neurobiol Aging. 33: 1125.e1-8. PMID: 22206847
3. Quantification of the brain proteome in Alzheimer's disease using multiplexed mass spectrometry.  |  Musunuri, S., et al. 2014. J Proteome Res. 13: 2056-68. PMID: 24606058
4. Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat.  |  Ganesan, MK., et al. 2014. Amino Acids. 46: 1681-96. PMID: 24682445
5. Proteomic investigation of the hippocampus in prenatally stressed mice implicates changes in membrane trafficking, cytoskeletal, and metabolic function.  |  Föcking, M., et al. 2014. Dev Neurosci. 36: 432-42. PMID: 25138076
6. Coexistence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies in Adult and Pediatric Patients.  |  Kunchok, A., et al. 2020. JAMA Neurol. 77: 257-259. PMID: 31657826
7. Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.  |  Dubey, D., et al. 2020. JAMA Neurol. 77: 1420-1429. PMID: 32744608
8. Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MS.  |  Banks, SA., et al. 2020. J Neurol Neurosurg Psychiatry.. PMID: 33372052
9. Clinical features and outcomes in primary nervous system histiocytic neoplasms.  |  Nathoo, N., et al. 2024. Blood Cancer J. 14: 101. PMID: 38902249
10. Innovation and optimization in autoimmune encephalitis trials: the design and rationale for the Phase 3, randomized study of satralizumab in patients with NMDAR-IgG-antibody-positive or LGI1-IgG-antibody-positive autoimmune encephalitis (CIELO).  |  Lee, ST., et al. 2024. Front Neurol. 15: 1437913. PMID: 39193150

The preferred Septin 5 antibody is Septin 5 Antibody (SP18): sc-20040.