SCAMP1 Antibody (D-1): sc-398154

SCAMP1 Antibody (D-1) is a mouse monoclonal IgM antibody that detects SCAMP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SCAMP1 antibody (D-1) is available as the non-conjugated form. Secretory carrier membrane proteins (SCAMPs) play a crucial role in cellular processes such as endocytosis, vesicle recycling, and membrane trafficking, which are essential for maintaining cellular homeostasis and communication. SCAMP1 is characterized by unique structural features, including multiple N-terminal NPF repeats and four highly conserved transmembrane regions, which facilitate interaction with EH domain proteins. These interactions are vital for the budding of transport vesicles from the plasma membrane and the Golgi complex, thereby influencing the dynamics of membrane trafficking. Notably, SCAMP1 is particularly abundant in neural tissue, where SCAMP1 is found in high concentrations within synaptic vesicles, underscoring importance in neurotransmitter release and synaptic function. Additionally, regulation of SCAMP1 through tyrosine phosphorylation by the epidermal growth factor receptor highlights involvement in signaling pathways that modulate cellular responses. With broad species reactivity and versatile applications, SCAMP1 monoclonal antibody (D-1) is an invaluable tool for researchers studying membrane dynamics and synaptic physiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SCAMP1 Antibody (D-1) References:

1. SCAMP1 function in endocytosis.  |  Fernández-Chacón, R., et al. 2000. J Biol Chem. 275: 12752-6. PMID: 10777571
2. Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.  |  Fernández-Chacón, R. and Südhof, TC. 2000. J Neurosci. 20: 7941-50. PMID: 11050114
3. Secretory carrier membrane proteins 31-35 define a common protein composition among secretory carrier membranes.  |  Brand, SH., et al. 1991. J Biol Chem. 266: 18949-57. PMID: 1717458
4. The glucose transporter GluT4 and secretory carrier membrane proteins (SCAMPs) colocalize in rat adipocytes and partially segregate during insulin stimulation.  |  Laurie, SM., et al. 1993. J Biol Chem. 268: 19110-7. PMID: 8360193
5. SCAMP 37, a new marker within the general cell surface recycling system.  |  Brand, SH. and Castle, JD. 1993. EMBO J. 12: 3753-61. PMID: 8404846
6. Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs).  |  Wu, TT. and Castle, JD. 1997. J Cell Sci. 110 (Pt 13): 1533-41. PMID: 9224770
7. Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.  |  Wu, TT. and Castle, JD. 1998. Mol Biol Cell. 9: 1661-74. PMID: 9658162
8. Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.  |  de Beer, T., et al. 1998. Science. 281: 1357-60. PMID: 9721102
9. Recognition specificity of individual EH domains of mammals and yeast.  |  Paoluzi, S., et al. 1998. EMBO J. 17: 6541-50. PMID: 9822599

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCAMP1 Antibody (D-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SCAMP1 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCAMP1 Antibody (D-1) Specifications

Alternate Product Name: SCAMP1

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 9-30

Epitope Target: SCAMP1

Epitope Species: human

Product Reactivity/Detection: SCAMP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SCAMP1 Antibody (D-1): P: Blocking Peptide