SBP-2 Antibody (C-10): sc-393651

SBP-2 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects SBP-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SBP-2 Antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SBP-2 protein plays a crucial role in the translation of selenoproteins, which are essential for various biological processes, including antioxidant defense and redox regulation. Specifically, SBP-2 binds to the selenocysteine insertion sequence (SECIS) element found in the 3′ untranslated region of selenoprotein mRNAs, facilitating the incorporation of selenocysteine during protein synthesis. This interaction is vital because selenoproteins, such as phospholipid hydroperoxide glutathione peroxidase, require selenocysteine for their enzymatic activity, which is critical for protecting cells from oxidative damage. Furthermore, SBP-2′s ability to associate with ribosomal complexes underscores its importance in the precise translation of selenoproteins, highlighting its potential role in cellular responses to oxidative stress and overall metabolic regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SBP-2 Antibody (C-10) References:

1. Purification, redox sensitivity, and RNA binding properties of SECIS-binding protein 2, a protein involved in selenoprotein biosynthesis.  |  Copeland, PR. and Driscoll, DM. 1999. J Biol Chem. 274: 25447-54. PMID: 10464275
2. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs.  |  Copeland, PR., et al. 2000. EMBO J. 19: 306-14. PMID: 10637234
3. SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy.  |  Low, SC., et al. 2000. EMBO J. 19: 6882-90. PMID: 11118223
4. Insight into mammalian selenocysteine insertion: domain structure and ribosome binding properties of Sec insertion sequence binding protein 2.  |  Copeland, PR., et al. 2001. Mol Cell Biol. 21: 1491-8. PMID: 11238886
5. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region.  |  Berry, MJ., et al. 1991. Nature. 353: 273-6. PMID: 1832744
6. Potential preventability of spontaneous bacterial peritonitis.  |  Ngamruengphong, S., et al. 2011. Dig Dis Sci. 56: 2728-34. PMID: 21394460
7. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials.  |  Montesi, SB., et al. 2012. J Clin Sleep Med. 8: 587-96. PMID: 23066375
8. Efficacy and safety of dapagliflozin in patients with type 2 diabetes and concomitant heart failure.  |  Kosiborod, M., et al. 2017. J Diabetes Complications. 31: 1215-1221. PMID: 28284707
9. Effects of isometric leg training on ambulatory blood pressure and morning blood pressure surge in young normotensive men and women.  |  Baross, AW., et al. 2022. Sci Rep. 12: 356. PMID: 35013400
10. The effect of isometric exercise training on arterial stiffness: A randomized crossover controlled study.  |  Edwards, JJ., et al. 2023. Physiol Rep. 11: e15690. PMID: 37208968
11. Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium.  |  Blodgett, JM., et al. 2025. Circulation. 151: 159-170. PMID: 39504653
12. An RNA-binding protein recognizes a mammalian selenocysteine insertion sequence element required for cotranslational incorporation of selenocysteine.  |  Lesoon, A., et al. 1997. Mol Cell Biol. 17: 1977-85. PMID: 9121445

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SBP-2 Antibody (C-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SBP-2 Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SBP-2 Antibody (C-10) Specifications

Alternate Product Name: SBP-2

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-19

Epitope Target: SBP-2

Epitope Species: rat

Product Reactivity/Detection: SBP-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SBP-2 Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin