RORγ Antibody (162C2a): sc-81371
- RORγ Antibody (162C2a) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of RORγ of human origin
- recommended for detection of RORγ of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RORγ Antibody (162C2a). This work is in progress.
RORγ Antibody (162C2a) is a mouse monoclonal IgG2a antibody that detects RORγ in human samples through western blotting (WB) and immunoprecipitation (IP) applications. RORγ, a member of the nuclear hormone receptor superfamily, plays a crucial role in regulating gene expression and is particularly important in the development and function of the immune system, as well as in the differentiation of T helper 17 cells. RORγ is primarily located in the nucleus, where RORγ binds to specific DNA sequences known as hormone response elements, functioning as a transcription factor. RORγ′s ability to act as a monomer, unlike many counterparts that form dimers, allows for unique regulatory mechanisms in gene expression. Additionally, RORγ is highly expressed in skeletal muscle, indicating potential involvement in muscle metabolism and function. The gene encoding RORγ is located on chromosome 1q21.3, and although RORγ is classified as an "orphan receptor" due to the absence of well-defined ligands, emerging evidence suggests that melatonin may serve as a natural ligand, further highlighting RORγ′s significance in various physiological processes. Anti-RORγ antibody (162C2a) is an essential tool for researchers investigating the multifaceted roles of RORγ in human health and disease.
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RORγ Antibody (162C2a) References:
- ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. | Wang, J., et al. 2016. Nat Med. 22: 488-96. PMID: 27019329
- Recent progress on nuclear receptor RORγ modulators. | Cyr, P., et al. 2016. Bioorg Med Chem Lett. 26: 4387-4393. PMID: 27542308
- RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. | Cai, D., et al. 2019. Nat Commun. 10: 4621. PMID: 31604910
- Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. | Song, X., et al. 2020. Nature. 577: 410-415. PMID: 31875848
- RORγ Structural Plasticity and Druggability. | Huang, M., et al. 2020. Int J Mol Sci. 21: PMID: 32727079
- The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries. | Hanna, BS., et al. 2023. Immunity. 56: 829-846.e8. PMID: 36822206
- Pterostilbene targets the molecular oscillator RORγ to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders. | Zhang, J., et al. 2024. Phytomedicine. 125: 155327. PMID: 38295659
- Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma. | Liu, Q., et al. 2024. Mol Ther. 32: 749-765. PMID: 38310356
- Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma. | Zheng, J., et al. 2024. Cell Rep Med. 5: 101519. PMID: 38692271
- Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. | Herrmann, A., et al. 2024. Antiviral Res. 231: 106008. PMID: 39306285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RORγ Antibody (162C2a) | sc-81371 | 100 µg/ml | $339.00 |