RNF152 Antibody (B-3): sc-398390
- RNF152 Antibody (B-3) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 65-130 mapping within an internal region of RNF152 of human origin
- recommended for detection of RNF152 of mouse, rat and human origin by WB, IP, IF and ELISA
- available conjugated to agarose for IP
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNF152 Antibody (B-3) for WB applications. These reagents are now offered in bundles with RNF152 Antibody (B-3) (see ordering information below).
RNF152 Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects RNF152 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNF152, also known as ring finger protein 152, is a 203 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for its role in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc ions, enabling RNF152 to interact with various substrates involved in cellular degradation processes. Proper functioning of RNF152 helps regulate protein turnover, thereby maintaining cellular homeostasis and preventing the accumulation of damaged or misfolded proteins. The gene encoding RNF152 is located on human chromosome 18, a region associated with several genetic disorders, including Trisomy 18 and various cancers, highlighting RNF152′s importance in both normal physiology and disease states. Anti-RNF152 antibody (B-3) is an essential tool for researchers investigating the mechanisms of protein degradation and the implications of RNF152 in various pathologies.
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RNF152 Antibody (B-3) References:
- RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. | Zhang, S., et al. 2010. Protein Cell. 1: 656-63. PMID: 21203937
- The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. | Deng, L., et al. 2015. Mol Cell. 58: 804-18. PMID: 25936802
- RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. | Xiong, MG., et al. 2020. EMBO Rep. 21: e48860. PMID: 31930677
- The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. | Okamoto, T., et al. 2020. Int J Mol Sci. 21: PMID: 32486221
- Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. | Wan, J., et al. 2021. Cancer Cell Int. 21: 122. PMID: 33602225
- Probiotic-derived p8 protein induce apoptosis via regulation of RNF152 in colorectal cancer cells. | Kim, BK., et al. 2021. Am J Cancer Res. 11: 746-759. PMID: 33791151
- [Effect of RNF152 on NO induced apoptosis of colon cancer cells]. | Zhao, XH., et al. 2021. Zhonghua Zhong Liu Za Zhi. 43: 528-532. PMID: 34034471
- RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression. | Zhu, D., et al. 2023. Am J Pathol. 193: 1603-1617. PMID: 37717980
- Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination. | Ueda, R., et al. 2024. Membranes (Basel). 14: PMID: 38392670
- Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis. | Tao, Y., et al. 2024. iScience. 27: 109659. PMID: 38706841
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNF152 Antibody (B-3) | sc-398390 | 200 µg/ml | $322.00 | |||
RNF152 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-538433 | 200 µg Ab; 10 µg BP | $361.00 | |||
RNF152 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-536046 | 200 µg Ab; 40 µg BP | $361.00 | |||
RNF152 Antibody (B-3): m-IgG2a BP-HRP Bundle | sc-548299 | 200 µg Ab; 10 µg BP | $361.00 | |||
RNF152 Antibody (B-3) AC | sc-398390 AC | 500 µg/ml, 25% agarose | $424.00 |