Molecular structure of Prostaglandin F2α isopropyl ester, CAS Number: 53764-90-2
Prostaglandin F2α isopropyl ester (CAS 53764-90-2)
Application:
Prostaglandin F2α isopropyl ester is a lipid-soluble prodrug of PGF2α
CAS Number:
53764-90-2
Molecular Weight:
396.6
Molecular Formula:
C23H40O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An ester prodrug of PGF2α with enhanced lipid solubility. Because of better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 µg dose reduces intraocular pressure by 68% after the fourth day of treatment.1
Prostaglandin F2α isopropyl ester (CAS 53764-90-2) References
- Effects of 0.005% latanoprost solution on intraocular pressure in healthy dogs and cats. | Studer, ME., et al. 2000. Am J Vet Res. 61: 1220-4. PMID: 11039551
- Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment. | Gaton, DD., et al. 2001. Arch Ophthalmol. 119: 1165-70. PMID: 11483084
- Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma. | Haneda, M., et al. 2006. Jpn J Ophthalmol. 50: 33-7. PMID: 16453185
- Identification of ocular matrix metalloproteinases present within the aqueous humor and iridocorneal drainage angle tissue of normal and glaucomatous canine eyes. | Weinstein, WL., et al. 2007. Vet Ophthalmol. 10 Suppl 1: 108-16. PMID: 17973842
- Dose-related effects of prostaglandin F2 alpha isopropylester on intraocular pressure, refraction, and pupil diameter in monkeys. | Crawford, KS. and Kaufman, PL. 1991. Invest Ophthalmol Vis Sci. 32: 510-9. PMID: 1878020
- Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome. | Kara, S., et al. 2014. Clin Ophthalmol. 8: 305-9. PMID: 24511224
- Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye. | Lu, W., et al. 2015. Invest Ophthalmol Vis Sci. 56: 3075-83. PMID: 26024091
- Twenty-four hour efficacy of glaucoma medications. | Konstas, AG., et al. 2015. Prog Brain Res. 221: 297-318. PMID: 26518084
- Influence of a cholesterol-lowering strain Lactobacillus plantarum LP3 isolated from traditional fermented yak milk on gut bacterial microbiota and metabolome of rats fed with a high-fat diet. | Ding, Z., et al. 2020. Food Funct. 11: 8342-8353. PMID: 32930686
- Morphofunctional Assessment of the Glycyrrhizinic Acid Effect on Myocardium of Rats under Adrenaline Loading[J]. | Bazekin G, Gatiyatullin I, Skovorodin E., 2020,. Pakistan Veterinary Journal. 40(3)..
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin F2α isopropyl ester, 1 mg | sc-205465 | 1 mg | $68.00 | |||
Prostaglandin F2α isopropyl ester, 5 mg | sc-205465A | 5 mg | $309.00 |