Prostaglandin E2 Ethanolamide CAS: 194935-38-1
MF: C22H37NO5
MW: 395.5
An analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells.

Prostaglandin E2 Ethanolamide (CAS 194935-38-1)

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Nomi alternativi: Dinoprostone Ethanolamide; PGE2-EA; Prostamide E2
Applicazione: Prostaglandin E2 Ethanolamide is an analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells
Numero CAS: 194935-38-1
Peso molecolare: 395.5
Formula molecolare: C22H37NO5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Prostaglandin E2 Ethanolamide is an analog of PGE2 (sc-201225) with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide (sc-200790; N-arachidonoylethanolamide), the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.


Referenze

1. Yu, M., et al. 1997. J. Biol. Chem. 272: 21181-21186. PMID: 9261124
2. Ross, R.A., et al. 2002. J. Pharmacol. Exp. Ther. 301: 900-907. PMID: 12023517
3. Weber, A., et al. 2004. J. Lipid Res. 45: 757-763. PMID: 14729864
4. Patsos, H.A., et al. 2005. Gut. 54: 1741-1750. PMID: 16099783
5. Glass, M., et al. 2005. J. Lipid Res. 46: 1364-1368. PMID: 15863842
6. Correa, F., et al. 2008. Biochem. J. 409: 761-770. PMID: 17961121

Stato fisico :
Solid
CONSERVAZIONE :
Store at -20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](CC(=O)[[email protected]@H]1C/C=C\\CCCC(=O)NCCO)O)O

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