Molecular structure of Prostaglandin D2 serinol amide, CAS Number: 63928-03-0
Prostaglandin D2 serinol amide (CAS 63928-03-0)
Alternate Names:
PGD2-SA
CAS Number:
63928-03-0
Molecular Weight:
425.56
Molecular Formula:
C23H39NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Exhibits cannabinoid (CB) agonist activity at the CB1 receptor,1 and is an important endogenous monoglyceride species,2 which is considered to be the natural ligand for the CB1 receptor. Can also be sequentially metabolized by COX-2 and specific PG synthases to form PG 2-glyceryl esters.3 In activated RAW 264.7 cells, PGD2 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway.3 PGD2 serinol amide (PGD2-SA) is a stable analog of PGD2 2-glyceryl ester. Unlike PGD2 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD2-SA will not isomerize to the less active primary (1-glyceryl) ester.
Prostaglandin D,[object Object], serinol amide (CAS 63928-03-0) References
- Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. | Kozak, KR., et al. 2002. J Biol Chem. 277: 44877-85. PMID: 12244105
- Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | Fowler, CJ. and Tiger, G. 2005. Biochem Pharmacol. 69: 1241-5. PMID: 15794945
- Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. | Sugiura, T., et al. 1997. J Biochem. 122: 890-5. PMID: 9399597
- 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. | Kondo, S., et al. 1998. FEBS Lett. 429: 152-6. PMID: 9650580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin D2 serinol amide, 1 mg | sc-224217 | 1 mg | $68.00 | |||
Prostaglandin D2 serinol amide, 5 mg | sc-224217A | 5 mg | $305.00 |