PP5 Antibody (E-12): sc-271612
- PP5 Antibody (E-12) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 71-240 mapping near the N-terminus of PP5 of human origin
- recommended for detection of PP5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PP5 Antibody (E-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with PP5 Antibody (E-12) (see ordering information below).
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PP5 Antibody (E-12) is a mouse monoclonal IgG2a antibody that detects PP5 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PP5, also known as protein phosphatase T, plays a crucial role in cellular regulation by dephosphorylating serine residues on target proteins, which is vital for processes such as mitosis and RNA biogenesis. PP5 is predominantly located in the nucleus, where PP5 interacts with key regulatory proteins like CDC16 and CDC27, thereby influencing cell cycle progression and gene expression. PP5 ′s ability to modulate phosphorylation states highlights PP5 ′s importance in maintaining cellular homeostasis and responding to various signaling pathways. Anti-PP5 antibody (E-12) is an essential tool for researchers studying the intricate mechanisms of protein regulation and cellular function.
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PP5 Antibody (E-12) References:
- Expression of serine proteinase inhibitor PP5/TFPI-2/MSPI decreases the invasive potential of human choriocarcinoma cells in vitro and in vivo. | Jin, M., et al. 2001. Gynecol Oncol. 83: 325-33. PMID: 11606093
- Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1). | Amable, L., et al. 2011. J Biol Chem. 286: 40413-22. PMID: 21921034
- Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease. | Ratajczak, T. 2015. Curr Mol Pharmacol. 9: 66-95. PMID: 25986567
- Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015). | Lajarín-Cuesta, R., et al. 2016. Expert Opin Ther Pat. 26: 389-407. PMID: 26853448
- Knockdown of protein phosphatase 5 inhibits ovarian cancer growth in vitro. | Zheng, X., et al. 2016. Oncol Lett. 11: 168-172. PMID: 26870184
- Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. | Chen, YL., et al. 2017. Biochem Pharmacol. 138: 49-60. PMID: 28528695
- Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. | Hsieh, FS., et al. 2017. Lung Cancer. 112: 81-89. PMID: 29191605
- Serine/threonine protein phosphatase 5 is a potential therapeutic target in cholangiocarcinoma. | Hu, MH., et al. 2018. Liver Int. 38: 2248-2259. PMID: 29797403
- AutoGVP: a dockerized workflow integrating ClinVar and InterVar germline sequence variant classification. | Kim, J., et al. 2024. Bioinformatics. 40: PMID: 38426335
- Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization. | Udagawa, K., et al. 1998. Placenta. 19: 217-23. PMID: 9548189
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP5 Antibody (E-12) | sc-271612 | 200 µg/ml | $322.00 | |||
PP5 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-540253 | 200 µg Ab; 10 µg BP | $361.00 |