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Polyuridylic acid potassium salt (CAS 27416-86-0)

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Application:
Polyuridylic acid potassium salt is A single-stranded RNA model compound
CAS Number:
27416-86-0
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polyuridylic acid potassium salt is extensively used in molecular biology research, particularly in the study of RNA structure and function. It serves as a homopolymeric RNA template in in vitro transcription experiments to understand RNA polymerase activity and specificity. This compound is also vital for investigating the binding affinity and specificity of RNA-binding proteins, which play roles in post-transcriptional regulation and RNA metabolism. Additionally, polyuridylic acid potassium salt is used in the study of RNA interference mechanisms and the development of siRNA-based gene silencing techniques.


Polyuridylic acid potassium salt (CAS 27416-86-0) References

  1. Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules.  |  Akeson, M., et al. 1999. Biophys J. 77: 3227-33. PMID: 10585944
  2. Template-directed synthesis of novel, nucleic acid-like structures.  |  Schwartz, AW. and Orgel, LE. 1985. Science. 228: 585-7. PMID: 11541994
  3. Polysaccharide-polynucleotide complexes VIII. Cation-induced complex formation between polyuridylic acid and schizophyllan.  |  Sakurai, K., et al. 2002. Biopolymers. 65: 1-9. PMID: 12209467
  4. Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid).  |  Westwood, A., et al. 2006. Vaccine. 24: 1736-43. PMID: 16278038
  5. Antitumor activity of polyuridylic acid in human soft tissue and bone sarcomas.  |  Adepoju, LJ. and Geiger, JD. 2010. J Surg Res. 164: e107-14. PMID: 20828720
  6. Pressure-induced dissociation of tight couple ribosomes.  |  Gross, M. and Jaenicke, R. 1990. FEBS Lett. 267: 239-41. PMID: 2199216
  7. TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface.  |  Crespo, MI., et al. 2013. J Immunol. 190: 948-60. PMID: 23284054
  8. Toll-like receptor 7 rapidly relaxes human airways.  |  Drake, MG., et al. 2013. Am J Respir Crit Care Med. 188: 664-72. PMID: 23924358
  9. Secure and effective gene delivery system of plasmid DNA coated by polynucleotide.  |  Kodama, Y., et al. 2015. J Drug Target. 23: 43-51. PMID: 25148610
  10. E.s.r. studies on the mechanism of hydroxyl radical-induced strand breakage of polyuridylic acid.  |  Hildenbrand, K. and Schulte-Frohlinde, D. 1989. Int J Radiat Biol. 55: 725-38. PMID: 2565934
  11. Enhancement of natural killer cell activity and 2-5A synthetase in operable breast cancer patients treated with polyadenylic; polyuridylic acid.  |  Hovanessian, AG., et al. 1985. Cancer. 55: 357-62. PMID: 2578083
  12. Purification and analysis of murine 2-5A-dependent RNase.  |  Silverman, RH., et al. 1988. J Biol Chem. 263: 7336-41. PMID: 3366783
  13. Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity.  |  Linsenmeier, M., et al. 2022. Nat Commun. 13: 3030. PMID: 35641495
  14. Ribosomes from Rauscher leukemia virus-infected cells and their response to Rauscher viral RNA and polyuridylic acid.  |  Naso WANG, CS., et al. 1973. Biochim Biophys Acta. 324: 346-64. PMID: 4762415
  15. The attachment of polyuridylic acid to reticulocyte ribosomes.  |  Williamson, AR. 1969. Biochem J. 111: 515-20. PMID: 5774476

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polyuridylic acid potassium salt, 10 mg

sc-215733
10 mg
$189.00

Polyuridylic acid potassium salt, 25 mg

sc-215733A
25 mg
$343.00

Re:   Polyuridylic acid potassium salt (CAS 27416-86-0) Hi,  What is the average molecular weight of this item???

Asked by: sergiomart
Thank you for your question. The molecular weight range for this item is 600-3,000 base pairs.
Answered by: Technical Support
Date published: 2021-09-20
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Rated 5 out of 5 by from Sogorin EA; et alSogorin EA; et al. (PubMed ID: 24460969) determined that polyuridiylic acid potassium salt can cause the bacterial ribosomes to effectively initiate translation. -SCBT Publication Review
Date published: 2015-04-28
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Polyuridylic acid potassium salt is rated 5.0 out of 5 by 1.
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