PNU 112455A hydrochloride CAS: 21886-12-4
MF: C10H11N5O2S•HCl
MW: 301.76
An ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25.

PNU 112455A hydrochloride (CAS 21886-12-4)

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Nomi alternativi: Cdk2/5 Inhibitor
Applicazione: PNU 112455A hydrochloride is an ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25
Numero CAS: 21886-12-4
Purezza: ≥95%
Peso molecolare: 301.76
Formula molecolare: C10H11N5O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PNU 112455A hydrochloride is a selective and ATP-competitive inhibitor of CDK2/cyclin E (Ki = 2 μM) and CDK5/p35 (p25) (Ki = 2 μM). It binds to the ATP-binding pocket of CDK2 and does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100 μM.


Referenze

P.M. Clare, et al.; J. Biol. Chem. 276, 48292 (2001).

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (5 mg/ml,clear solution), and water.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
293-295° C
Punto di ebollizione :
578.9° C at 760 mmHg (Predicted)
Indice di rifrazione :
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00023272
SMILES :
C1=CC(=CC=C1NC2=NC=NC(=C2)N)S(=O)(=O)N.Cl

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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