Molecular structure of (±)17-HDoHE, CAS Number: 90780-52-2
(±)17-HDoHE (CAS 90780-52-2)
Alternate Names:
17-hydroxy Docosahexaenoic Acid
Application:
(±)17-HDoHE is an inhibitor of platelet aggregation and smooth muscle contraction
CAS Number:
90780-52-2
Molecular Weight:
344.49
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)17-HDoHE is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It has been found to be produced from incubations of DHA in rat brain, intestinal microsomes and liver. (±)17-HDoHE may act to inhibit U-46619-induced rabbit and rat aortic smooth muscle contraction (IC50 = 4.9 and 7.2 muM, respectively). It is also a potential marker of oxidative stress in brain and retina where DHA is abundant.
(±)17-HDoHE (CAS 90780-52-2) References
- Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. | Kim, HY., et al. 1990. Prostaglandins. 40: 473-90. PMID: 2147773
- Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice. | Rodriguez-Echevarria, R., et al. 2018. World J Gastroenterol. 24: 461-474. PMID: 29398867
- Oxidation of docosahexaenoic acid by rat liver microsomes. | VanRollins, M., et al. 1984. J Biol Chem. 259: 5776-83. PMID: 6232277
- Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. | VanRollins, M. and Murphy, RC. 1984. J Lipid Res. 25: 507-17. PMID: 6234372
- Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. | Karanian, JW., et al. 1994. J Pharmacol Exp Ther. 270: 1105-9. PMID: 7932158
- High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate. | Yamane, M., et al. 1994. J Chromatogr. 652: 123-36. PMID: 8006098
- Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation. | Reynaud, D., et al. 1993. Anal Biochem. 214: 165-70. PMID: 8250220
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)17-HDoHE, 25 µg | sc-205059 | 25 µg | $60.00 | |||
(±)17-HDoHE, 50 µg | sc-205059A | 50 µg | $116.00 |