Pim-2 Antibody (F-11): sc-137049

Pim-2 Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects Pim-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pim-2, a serine/threonine kinase encoded by the pim-2 gene, plays a crucial role in various cellular processes, including cell survival, proliferation, and differentiation, making Pim-2 a significant player in oncogenesis. Pim-2 is primarily located in the cytoplasm and translocates to the nucleus under certain conditions, which is vital for regulating gene expression and cellular responses to stress. Pim-2′s ability to modulate these pathways highlights Pim-2′s importance in both normal cellular physiology and in the pathogenesis of diseases such as leukemia and lymphoma. Furthermore, Pim-2 is involved in the formation and maintenance of Long-Term Potentiation (LTP), a process essential for synaptic plasticity and memory formation, underscoring Pim-2′s relevance in neurobiology. With diverse roles and implications in cancer and neurodegenerative diseases, anti-Pim-2 antibody (F-11) serves as a valuable tool for researchers aiming to explore the intricate functions of this kinase in various biological contexts.

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Pim-2 Antibody (F-11) References:

1. The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines.  |  White, E. 2003. Genes Dev. 17: 1813-6. PMID: 12897050
2. Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis.  |  Acevedo, ML., et al. 2010. Arch Biochem Biophys. 495: 28-34. PMID: 20026028
3. Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.  |  Nakano, H., et al. 2012. J Med Chem. 55: 5151-64. PMID: 22540945
4. Significant differences in integration sites of Moloney murine leukemia virus/Moloney murine sarcoma virus retroviral vector carrying recombinant coagulation factor IX in two human cell lines.  |  Castilho-Fernandes, A., et al. 2015. Biotechnol Lett. 37: 991-1001. PMID: 25650340
5. B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer.  |  Zhao, Q., et al. 2016. Onco Targets Ther. 9: 5203-8. PMID: 27578986
6. Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.  |  Teramachi, J., et al. 2018. Br J Haematol. 180: 581-585. PMID: 27748523
7. Inhibition of Pim-2 kinase by LT-171-861 promotes DNA damage and exhibits enhanced lethal effects with PARP inhibitor in multiple myeloma.  |  Zhao, C., et al. 2021. Biochem Pharmacol. 190: 114648. PMID: 34111425
8. Proviral Integration of Moloney Virus-2 (PIM-2) Expression Level as a Prognostic Marker in Patients with Acute Myeloid Leukemia.  |  Hamed, G., et al. 2022. Int J Gen Med. 15: 4247-4258. PMID: 35480994
9. Localization of a Moloney murine leukemia virus integration site gene, Mlvi2, on rat chromosome 2.  |  Kunieda, T., et al. 1996. Mamm Genome. 7: 924-5. PMID: 8995772

The preferred Pim-2 antibody is Pim-2 Antibody (1D12): sc-13514.