PHTPP (CAS 805239-56-9)
See product citations (25)
QUICK LINKS
PHTPP is a synthetic compound used in molecular biology and endocrinology research as a selective antagonist for the estrogen receptor beta (ERβ). Its ability to bind to this receptor with high affinity while showing minimal interaction with estrogen receptor alpha (ERα) makes it useful for dissecting the distinct biological roles of these two receptor subtypes. Researchers employ PHTPP to study the signaling pathways mediated by ERβ, which are important for understanding the differential effects of estrogen in various tissues. By inhibiting ERβ, PHTPP helps in elucidating its contributions to cellular processes such as proliferation, differentiation, and apoptosis. The compound also aids in the investigation of the potential role of ERβ in certain diseases and in the normal physiological functions of estrogen in both males and females.
PHTPP (CAS 805239-56-9) References
- An in silico exploration of the interaction mechanism of pyrazolo[1,5-a]pyrimidine type CDK2 inhibitors. | Li, Y., et al. 2013. Mol Biosyst. 9: 2266-81. PMID: 23864105
- 17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells. | Son, HJ., et al. 2020. Korean J Intern Med. 35: 310-319. PMID: 30336658
- Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function. | Du, Y., et al. 2019. Reproduction. 157: 179-188. PMID: 30500775
- The regulation and signalling of anti-Müllerian hormone in human granulosa cells: relevance to polycystic ovary syndrome. | Dilaver, N., et al. 2019. Hum Reprod. 34: 2467-2479. PMID: 31735954
- A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve. | Chakravarthi, VP., et al. 2020. Endocrinology. 161: PMID: 32141511
- ERβ and NFκB-Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells. | Kowalska, K., et al. 2020. Toxins (Basel). 12: PMID: 32235729
- 8-prenylgenistein exerts osteogenic effects via ER α and Wnt-dependent signaling pathway. | Qiu, ZC., et al. 2020. Exp Cell Res. 395: 112186. PMID: 32698024
- Estradiol Induces Epithelial to Mesenchymal Transition of Human Glioblastoma Cells. | Hernández-Vega, AM., et al. 2020. Cells. 9: PMID: 32825553
- Sunitinib increases the cancer stem cells and vasculogenic mimicry formation via modulating the lncRNA-ECVSR/ERβ/Hif2-α signaling. | He, M., et al. 2022. Cancer Lett. 524: 15-28. PMID: 34461182
- Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway. | Zhuo, Y., et al. 2022. Inflammation. 45: 824-837. PMID: 34807349
- β-Estradiol inhibits melatonin synthesis and melatonin receptor expression in sheep granulosa cells. | Duan, H., et al. 2022. Gene. 814: 146128. PMID: 34971752
- Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats. | Azizian, H., et al. 2022. Horm Mol Biol Clin Investig. 43: 427-436. PMID: 35512107
- Estrogen Acts Through Estrogen Receptor-β to Promote Mannan-Induced Psoriasis-Like Skin Inflammation. | Wu, H., et al. 2022. Front Immunol. 13: 818173. PMID: 35663991
- Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice. | Wang, M., et al. 2022. Oxid Med Cell Longev. 2022: 1330928. PMID: 36425058
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHTPP, 10 mg | sc-204191 | 10 mg | $193.00 | |||
PHTPP, 20 mg | sc-204191C | 20 mg | $364.00 | |||
PHTPP, 50 mg | sc-204191A | 50 mg | $813.00 | |||
PHTPP, 100 mg | sc-204191B | 100 mg | $1248.00 |