PDE6D Antibody (C-8): sc-166855

PDE6D Antibody (C-8) is a mouse monoclonal IgG2a antibody that detects phosphodiesterase 6D in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE6D plays a crucial role in the retina, where phosphodiesterase 6D is involved in the phototransduction cascade, a process essential for converting light into electrical signals in the visual system. PDE6D (C-8) antibody specifically detects phosphodiesterase 6D in the photoreceptor cells of the retina, where phosphodiesterase 6D regulates cyclic guanosine monophosphate (cGMP) levels, thereby influencing ion channel activity and contributing to visual response. Proper functioning of phosphodiesterase 6D is vital for maintaining photoreceptor health and function, and dysregulation can lead to retinal diseases and vision impairment. Anti-PDE6D antibody (C-8) provides reliable detection, facilitating research into retinal signaling and potential implications in ocular pathologies. Additionally, phosphodiesterase 6D contains two N-linked glycosylation sites, which are significant for stability and function, further underscoring the importance of PDE6D (C-8) monoclonal antibody in studying post-translational modifications that may affect protein interactions and activity.

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PDE6D Antibody (C-8) References:

1. ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.  |  Humbert, MC., et al. 2012. Proc Natl Acad Sci U S A. 109: 19691-6. PMID: 23150559
2. A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.  |  Thomas, S., et al. 2014. Hum Mutat. 35: 137-46. PMID: 24166846
3. Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.  |  Zhang, H., et al. 2014. Adv Exp Med Biol. 801: 487-93. PMID: 24664735
4. PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner.  |  Lee, JJ. and Seo, S. 2015. EMBO Rep. 16: 1581-2. PMID: 26553938
5. RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.  |  Dutta, N. and Seo, S. 2016. Biol Open. 5: 1283-9. PMID: 27493202
6. Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates in Dictyostelium that contribute to chemotaxis towards cAMP.  |  Baumgardner, K., et al. 2018. Environ Microbiol. 20: 1888-1903. PMID: 29626371
7. A novel PDE6D mutation in a patient with Joubert syndrome type 22 (JBTS22).  |  Mégarbané, A., et al. 2019. Eur J Med Genet. 62: 103576. PMID: 30423442
8. PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity.  |  Siddiqui, FA., et al. 2020. ACS Omega. 5: 832-842. PMID: 31956834
9. Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects.  |  Canovas Nunes, S., et al. 2022. Blood Cancer J. 12: 64. PMID: 35422065
10. Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse.  |  Lorenz, B., et al. 1998. Eur J Hum Genet. 6: 283-90. PMID: 9781033

The preferred PDE6D antibody is PDE6D Antibody (A-8): sc-376724.