PARP-3 Antibody (B-7): sc-390771
- PARP-3 Antibody (B-7) is a mouse monoclonal IgG2a κ PARP-3 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 139-219 mapping within an internal region of PARP-3 of human origin
- PARP-3 Antibody (B-7) is recommended for detection of PARP-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PARP-3 Antibody (B-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-390771 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PARP-3 Antibody (B-7) for WB applications. These reagents are now offered in bundles with PARP-3 Antibody (B-7) (see ordering information below).
PARP-3 Antibody (B-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects PARP-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PARP-3 (B-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PARP-3 protein, also known as poly(ADP-ribose) polymerase-3, plays a crucial role in the base excision repair (BER) pathway by catalyzing the poly(ADP-ribosyl)ation of nuclear proteins, a vital post-translational modification that occurs in response to DNA damage. This modification is essential for the recruitment of DNA repair proteins to sites of damage, thereby facilitating the repair of DNA strand breaks and maintaining genomic stability. PARP-3 is predominantly located in the nucleus and is particularly abundant in actively dividing tissues such as the kidney, skeletal muscle, liver, heart, and spleen. Notably, human PARP-3 is mapped to chromosome 3p21-3-p21.1, a region frequently altered in solid malignant tumors, highlighting its potential significance in cancer biology and therapeutic targeting.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PARP-3 Antibody (B-7) References:
- pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. | Berghammer, H., et al. 1999. FEBS Lett. 449: 259-63. PMID: 10338144
- PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. | Amé, JC., et al. 1999. J Biol Chem. 274: 17860-8. PMID: 10364231
- Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein. | Still, IH., et al. 1999. Genomics. 62: 533-6. PMID: 10644454
- Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. | Glowacki, G., et al. 2001. Gene. 275: 267-77. PMID: 11587854
- Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. | Schreiber, V., et al. 2002. J Biol Chem. 277: 23028-36. PMID: 11948190
- PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. | Augustin, A., et al. 2003. J Cell Sci. 116: 1551-62. PMID: 12640039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARP-3 Antibody (B-7) | sc-390771 | 200 µg/ml | $322.00 | |||
PARP-3 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-530256 | 200 µg Ab; 10 µg BP | $361.00 | |||
PARP-3 Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-523675 | 200 µg Ab, 40 µg BP | $361.00 | |||
PARP-3 Antibody (B-7) X | sc-390771 X | 200 µg/0.1 ml | $322.00 | |||
PARP-3 Antibody (B-7) AC | sc-390771 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PARP-3 Antibody (B-7) HRP | sc-390771 HRP | 200 µg/ml | $322.00 | |||
PARP-3 Antibody (B-7) FITC | sc-390771 FITC | 200 µg/ml | $336.00 | |||
PARP-3 Antibody (B-7) PE | sc-390771 PE | 200 µg/ml | $349.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 488 | sc-390771 AF488 | 200 µg/ml | $364.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 546 | sc-390771 AF546 | 200 µg/ml | $364.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 594 | sc-390771 AF594 | 200 µg/ml | $364.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 647 | sc-390771 AF647 | 200 µg/ml | $364.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 680 | sc-390771 AF680 | 200 µg/ml | $364.00 | |||
PARP-3 Antibody (B-7) Alexa Fluor® 790 | sc-390771 AF790 | 200 µg/ml | $364.00 |