Date published: 2026-7-29

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Paraformaldehyde (CAS 30525-89-4)

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Alternate Names:
Polyoxymethylene
Application:
Paraformaldehyde is a disinfectant and fixation reagent
CAS Number:
30525-89-4
Purity:
≥88%
Molecular Weight:
30.03 (as monomer)
Molecular Formula:
(CH2O)n
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Paraformaldehyde has documented uses as a disinfectant, fungicide, fixation reagent and in the preparation of formaldehyde. In fluorescence studies, paraformaldehyde has been used as as a formalin fixative to fix cells and tissues. To use the chemical as a fixative, it must be converted to the monomer formaldehyde by heating as formaldehyde is the active chemical in fixation.


Paraformaldehyde (CAS 30525-89-4) References

  1. Studies on the structure of autonomic nerves in the small intestine, correlating the silver-impregnated image in light microscopy with the permanganate-fixed ultrastructure in electronmicrscopy.  |  RICHARDSON, KC. 1960. J Anat. 94: 457-72. PMID: 13741298
  2. Paraformaldehyde-resistant starch-fermenting bacteria in 'starch-base' drilling mud.  |  MYERS, GE. 1962. Appl Microbiol. 10: 418-21. PMID: 13936949
  3. Paraformaldehyde induces elevation of intracellular calcium and phosphatidylserine externalization in platelets.  |  Wong, K., et al. 2006. Thromb Res. 117: 537-42. PMID: 15951006
  4. Iatrogenic paraformaldehyde orofacial chemical burn.  |  Rihani, FB. and Al-Bataineh, MM. 2013. BMJ Case Rep. 2013: PMID: 23355591
  5. Paraformaldehyde Fixation May Lead to Misinterpretation of the Subcellular Localization of Plant High Mobility Group Box Proteins.  |  Li, MW., et al. 2015. PLoS One. 10: e0135033. PMID: 26270959
  6. Organocatalytic Enantioselective Vinylogous Aldol Reaction of 5-Alkyl-4-Nitroisoxazoles to Paraformaldehyde.  |  Zhu, B., et al. 2018. J Org Chem. 83: 11350-11358. PMID: 30080046
  7. Alternative sanitizers to paraformaldehyde for incubation of fertile eggs.  |  Oliveira, GDS., et al. 2020. Poult Sci. 99: 2001-2006. PMID: 32241483
  8. Base-controlled divergent synthesis of vinyl sulfones from (benzylsulfonyl)benzenes and paraformaldehyde.  |  Xiao, F., et al. 2020. Org Biomol Chem. 18: 3527-3535. PMID: 32334421
  9. An optimized fixation method containing glyoxal and paraformaldehyde for imaging nuclear bodies.  |  Yao, RW., et al. 2021. RNA. 27: 725-733. PMID: 33846273
  10. The Combination of Paraformaldehyde and Glutaraldehyde Is a Potential Fixative for Mitochondria.  |  Qin, Y., et al. 2021. Biomolecules. 11: PMID: 34068806
  11. High-throughput RNA sequencing of paraformaldehyde-fixed single cells.  |  Phan, HV., et al. 2021. Nat Commun. 12: 5636. PMID: 34561439
  12. Basic structure and cytocompatibility of giant membrane vesicles derived from paraformaldehyde-exposed human cells.  |  Okada, S., et al. 2022. J Biochem. 171: 339-347. PMID: 34928331
  13. Hydrogen Production from Formaldehyde and Paraformaldehyde in Water under Additive-Free Conditions: Catalytic Reactions and Mechanistic Insights.  |  Patra, S., et al. 2022. Inorg Chem. 61: 4618-4626. PMID: 35258976
  14. Reaction of Corroles with Sarcosine and Paraformaldehyde: A New Facet of Corrole Chemistry.  |  Barata, JFB., et al. 2022. Int J Mol Sci. 23: PMID: 36362367
  15. Formalin fixation for electron microscopy: a re-evaluation.  |  Carson, FL., et al. 1973. Am J Clin Pathol. 59: 365-73. PMID: 4119901

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Paraformaldehyde, 25 g

sc-253236
25 g
$36.00

Paraformaldehyde, 100 g

sc-253236A
100 g
$42.00

Paraformaldehyde, 500 g

sc-253236B
500 g
$48.00