p38 gamma MAPK12 Antibody (E-4): sc-398546

p38 gamma MAPK12 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects p38 gamma MAPK12 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 gamma MAPK12 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p38 gamma MAPK12, also known as MAPK12, plays a crucial role in cellular responses to stress and inflammation, acting as a key regulator in signaling pathways that control cell differentiation, apoptosis, and cytokine production. p38 gamma MAPK12 is primarily located in the cytoplasm, where activation occurs in response to various extracellular stimuli, such as pro-inflammatory cytokines and environmental stressors. Cytoplasmic localization is essential for function, allowing rapid response to signals and modulation of downstream effects, thereby influencing critical processes such as cell survival and immune responses. p38 gamma MAPK12 interacts with other proteins in the MAP kinase signaling cascade, further amplifying roles in cellular signaling networks. Phosphorylation of p38 gamma MAPK12 on threonine and tyrosine residues is a vital post-translational modification that activates kinase activity, enabling phosphorylation of target proteins and propagation of signaling pathways essential for maintaining cellular homeostasis and responding to stress.

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p38 gamma MAPK12 Antibody (E-4) References:

1. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.  |  Tamura, K., et al. 2000. Cell. 102: 221-31. PMID: 10943842
2. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  |  Sudo, T., et al. 2002. Biochem Biophys Res Commun. 291: 838-43. PMID: 11866441
3. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).  |  Court, NW., et al. 2002. J Mol Cell Cardiol. 34: 413-26. PMID: 11991731
4. Active mutants of the human p38alpha mitogen-activated protein kinase.  |  Diskin, R., et al. 2004. J Biol Chem. 279: 47040-9. PMID: 15284239
5. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.  |  Zohn, IE., et al. 2006. Cell. 125: 957-69. PMID: 16751104
6. p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.  |  Kwong, J., et al. 2009. J Biol Chem. 284: 11237-46. PMID: 19251701
7. p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9.  |  Loesch, M., et al. 2010. J Biol Chem. 285: 15149-15158. PMID: 20231272
8. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.  |  Sabio, G., et al. 2010. J Cell Sci. 123: 2596-604. PMID: 20605917
9. Molecular cloning of human p38 MAP kinase.  |  Han, J., et al. 1995. Biochim Biophys Acta. 1265: 224-7. PMID: 7696354
10. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.  |  Lee, JC., et al. Nature. 372: 739-46. PMID: 7997261
11. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
12. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.  |  Li, Z., et al. 1996. Biochem Biophys Res Commun. 228: 334-40. PMID: 8920915

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p38 gamma MAPK12 Antibody (E-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p38 gamma MAPK12 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p38 gamma MAPK12 Antibody (E-4) Specifications

Alternate Product Name: p38 gamma MAPK12

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 311-367

Epitope Target: p38 gamma MAPK12

Epitope Species: human

Product Reactivity/Detection: p38 gamma MAPK12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p38 gamma MAPK12 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin